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PMID: 21068152 Published · ppublish English Journal Article Review

Biogenesis of nuclear bodies.

Cold Spring Harbor perspectives in biology ·Vol. 2 ·No. 12 ·2010-12-00 ·Pages a000711

Dundr M, Misteli T

Abstract

The nucleus is unique amongst cellular organelles in that it contains a myriad of discrete suborganelles. These nuclear bodies are morphologically and molecularly distinct entities, and they host specific nuclear processes. Although the mode of biogenesis appears to differ widely between individual nuclear bodies, several common design principles are emerging, particularly, the ability of nuclear bodies to form de novo, a role of RNA as a structural element and self-organization as a mode of formation. The controlled biogenesis of nuclear bodies is essential for faithful maintenance of nuclear architecture during the cell cycle and is an important part of cellular responses to intra- and extracellular events.

MeSH Terms
Biosynthetic Pathways/physiology Cell Nucleus Structures/classification,metabolism,physiology Inheritance Patterns/genetics Mitosis/genetics,physiology RNA/metabolism
Chemicals
RNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dundr Miroslav
Department of Cell Biology, Rosalind Franklin University of Medicine and Science, North Chicago, Ilinois 60064, USA. mirek.dundr@rosalindfranklin.edu
Misteli Tom
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a000711
Email
mirek.dundr@rosalindfranklin.edu
Published
2010-12-00
Epub
2010-00-10
Pages
a000711
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC2982170
Subset
IM
Grants
Intramural NIH HHS · Z01 BC010309-10 · United States
External Links
PubMed source DOI: 10.1101/cshperspect.a000711 PMC Full Text View journal details
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