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PMID: 19289796 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

In search of nonribosomal nucleolar protein function and regulation.

The Journal of cell biology ·Vol. 184 ·No. 6 ·2009-03-23 ·Pages 771-6

Pederson T, Tsai RY

Abstract

The life of the nucleolus has proven to be more colorful and multifaceted than had been envisioned a decade ago. A large number of proteins found in this subnuclear compartment have no identifiable tie either to the ribosome biosynthetic pathway or to the other newly established activities occurring within the nucleolus. The questions of how and why these proteins end up in this subnuclear compartment remain unanswered and are the focus of intense current interest. This review discusses our thoughts on the discovery of nonribosomal proteins in the nucleolus.

MeSH Terms
Animals Cell Cycle Cell Cycle Proteins/metabolism Cell Nucleolus/enzymology,metabolism Humans Nuclear Proteins/metabolism Phosphoric Monoester Hydrolases/metabolism Protein Transport RNA Precursors/metabolism RNA, Ribosomal/metabolism Ribosomal Proteins/metabolism
Chemicals
Cell Cycle Proteins Nuclear Proteins RNA Precursors RNA, Ribosomal Ribosomal Proteins Phosphoric Monoester Hydrolases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pederson Thoru
Program in Cell Dynamics, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Tsai Robert Y L
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
1540-8140
DOI
10.1083/jcb.200812014
Published
2009-03-23
Epub
2009-00-16
Pages
771-6
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2699146
Subset
IM
Grants
NCI NIH HHS · R01 CA113750 · United States
NIGMS NIH HHS · GM 21595 · United States
NCI NIH HHS · CA 113750 · United States
NIGMS NIH HHS · GM 60551 · United States
NIGMS NIH HHS · R01 GM060551 · United States
External Links
PubMed source DOI: 10.1083/jcb.200812014 PMC Full Text View journal details
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