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PMID: 20880716 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

microRNAs and cholesterol metabolism.

Trends in endocrinology and metabolism: TEM ·Vol. 21 ·No. 12 ·2010-12-00 ·Pages 699-706

Moore KJ, Rayner KJ, Suárez Y, Fernández-Hernando C

Abstract

Cholesterol metabolism is tightly regulated at the cellular level. In addition to classic transcriptional regulation of cholesterol metabolism (e.g. by SREBP and LXR), members of a class of non-coding RNAs termed microRNAs (miRNAs) have recently been identified to be potent post-transcriptional regulators of lipid metabolism genes, including cholesterol homeostasis. We and others have recently shown that miR-33 regulates cholesterol efflux and HDL biogenesis by downregulating the expression of the ABC transporters, ABCA1 and ABCG1. In addition to miR-33, miR-122 and miR-370 have been shown to play important roles in regulating cholesterol and fatty acid metabolism. These new data suggest important roles of microRNAs in the epigenetic regulation of cholesterol metabolism and have opened new avenues for the treatment of dyslipidemias.

MeSH Terms
ATP-Binding Cassette Transporters/genetics,metabolism Animals Cholesterol/metabolism Humans Lipid Metabolism/genetics,physiology MicroRNAs/genetics,metabolism Models, Biological
Chemicals
ATP-Binding Cassette Transporters MicroRNAs Cholesterol
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Moore Kathryn J
Department of Medicine, New York University School of Medicine, New York, NY 10016, USA. kathryn.moore@nyumc.org
Rayner Katey J
Suárez Yajaira
Fernández-Hernando Carlos
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Article Info
Journal
Trends in endocrinology and metabolism: TEM
Abbr.
Trends Endocrinol Metab
ISSN
1879-3061
DOI
10.1016/j.tem.2010.08.008
Email
kathryn.moore@nyumc.org
Published
2010-12-00
Epub
2010-00-27
Pages
699-706
Language
English
Region
United States
NLM ID
9001516
PMCID
PMC2991595
Subset
IM
Grants
NIA NIH HHS · R01 AG020255-10 · United States
NHLBI NIH HHS · P30 HL101270 · United States
NHLBI NIH HHS · 1P30HL101270-01 · United States
NIA NIH HHS · R01AG020055 · United States
NIA NIH HHS · R01 AG020255 · United States
External Links
PubMed source DOI: 10.1016/j.tem.2010.08.008 PMC Full Text View journal details
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