Home LiteratureArticle Details
PMID: 12370265 Published · ppublish English Journal Article Review

Regulation and mechanisms of macrophage cholesterol efflux.

The Journal of clinical investigation ·Vol. 110 ·No. 7 ·2002-10-00 ·Pages 899-904

Tall AR, Costet P, Wang N

Abstract

暂无摘要

MeSH Terms
ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters/physiology Animals Arteriosclerosis/etiology,therapy Biological Transport Cholesterol/metabolism DNA-Binding Proteins Humans Liver X Receptors Macrophages/metabolism Membrane Microdomains/metabolism Mice Mice, Knockout Orphan Nuclear Receptors Receptors, Cytoplasmic and Nuclear/physiology
Chemicals
ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters DNA-Binding Proteins Liver X Receptors Orphan Nuclear Receptors Receptors, Cytoplasmic and Nuclear Cholesterol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tall Alan R
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA. art1@columbia.edu
Costet Philippe
Wang Nan
References (49)
49 references, click to expand
  1. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.
    Mol Cell Biol. 2002 Apr;22(8):2607-19 PMID: 11909955
  2. Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol.
    J Biol Chem. 1991 Feb 15;266(5):3080-6 PMID: 1993681
  3. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.
    Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6298-303 PMID: 11972062
  4. Synthetic LXR ligand inhibits the development of atherosclerosis in mice.
    Proc Natl Acad Sci U S A. 2002 May 28;99(11):7604-9 PMID: 12032330
  5. Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradation.
    J Biol Chem. 2002 Jun 21;277(25):22426-9 PMID: 11950847
  6. Increased ABCA1 activity protects against atherosclerosis.
    J Clin Invest. 2002 Jul;110(1):35-42 PMID: 12093886
  7. Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I.
    J Biol Chem. 2002 Sep 6;277(36):33178-87 PMID: 12084722
  8. Do oxysterols control cholesterol homeostasis?
    J Clin Invest. 2002 Sep;110(6):725-30 PMID: 12235099
  9. Interferon-gamma induces downregulation of Tangier disease gene (ATP-binding-cassette transporter 1) in macrophage-derived foam cells.
    Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1565-71 PMID: 10845873
  10. Binding of high density lipoprotein (HDL) and discoidal reconstituted HDL to the HDL receptor scavenger receptor class B type I. Effect of lipid association and APOA-I mutations on receptor binding.
    J Biol Chem. 2000 Jul 14;275(28):21262-71 PMID: 10801839
  11. Scavenger receptor class B, type I-mediated [3H]cholesterol efflux to high and low density lipoproteins is dependent on lipoprotein binding to the receptor.
    J Biol Chem. 2000 Sep 29;275(39):29993-30001 PMID: 11001950
  12. Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1.
    J Biol Chem. 2000 Oct 20;275(42):33053-8 PMID: 10918065
  13. ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages.
    J Biol Chem. 2000 Nov 3;275(44):34508-11 PMID: 10918070
  14. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
    Genes Dev. 2000 Nov 15;14(22):2819-30 PMID: 11090130
  15. Apolipoprotein specificity for lipid efflux by the human ABCAI transporter.
    Biochem Biophys Res Commun. 2001 Jan 26;280(3):818-23 PMID: 11162594
  16. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.
    Mol Cell. 2001 Jan;7(1):161-71 PMID: 11172721
  17. Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.
    Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2610-5 PMID: 11226287
  18. Localization of human ATP-binding cassette transporter 1 (ABC1) in normal and atherosclerotic tissues.
    Arterioscler Thromb Vasc Biol. 2001 Mar;21(3):378-85 PMID: 11231917
  19. Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter.
    J Biol Chem. 2001 Mar 30;276(13):9955-60 PMID: 11150301
  20. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.
    Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11 PMID: 11309497
  21. ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space.
    J Biol Chem. 2001 May 4;276(18):15137-45 PMID: 11328826
  22. Regulation and activity of the human ABCA1 gene in transgenic mice.
    J Biol Chem. 2001 May 25;276(21):18046-51 PMID: 11279093
  23. Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study.
    Lancet. 2002 Jan 5;359(9300):37-42 PMID: 11809185
  24. Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1.
    J Biol Chem. 2002 Feb 15;277(7):5692-7 PMID: 11741998
  25. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.
    Proc Natl Acad Sci U S A. 2001 May 22;98(11):6027-32 PMID: 11371634
  26. ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein.
    J Biol Chem. 2001 Jun 29;276(26):23742-7 PMID: 11309399
  27. Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: identification of N-linked glycosylation sites.
    J Biol Chem. 2001 Jun 29;276(26):23539-46 PMID: 11320094
  28. Cellular localization and trafficking of the human ABCA1 transporter.
    J Biol Chem. 2001 Jul 20;276(29):27584-90 PMID: 11349133
  29. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells.
    J Biol Chem. 2001 Oct 19;276(42):38378-87 PMID: 11504730
  30. Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes.
    J Biol Chem. 2001 Nov 23;276(47):43564-9 PMID: 11559713
  31. Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.
    J Biol Chem. 2001 Nov 30;276(48):44976-83 PMID: 11579092
  32. Cellular cholesterol efflux.
    Biochim Biophys Acta. 2001 Oct 31;1533(3):175-89 PMID: 11731329
  33. Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate.
    J Biol Chem. 2001 Dec 28;276(52):48702-8 PMID: 11641412
  34. The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice.
    Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):407-12 PMID: 11752403
  35. Cyclic AMP-specific phosphodiesterase 4 inhibitors promote ABCA1 expression and cholesterol efflux.
    Biochem Biophys Res Commun. 2002 Jan 18;290(2):663-9 PMID: 11785950
  36. Coronary heart disease prevalence and other clinical features in familial high-density lipoprotein deficiency (Tangier disease).
    Ann Intern Med. 1980 Aug;93(2):261-6 PMID: 7406376
  37. The effects of subfractions of high density lipoprotein on cholesterol efflux from cultured fibroblasts. Regulation of low density lipoprotein receptor activity.
    J Biol Chem. 1981 Aug 25;256(16):8348-56 PMID: 6267041
  38. Mechanisms and consequences of cellular cholesterol exchange and transfer.
    Biochim Biophys Acta. 1987 Jun 24;906(2):223-76 PMID: 3297153
  39. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI.
    Nature. 1991 Sep 19;353(6341):265-7 PMID: 1910153
  40. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse.
    Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9607-11 PMID: 7937814
  41. Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease.
    J Clin Invest. 1995 Jul;96(1):78-87 PMID: 7615839
  42. Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.
    J Clin Invest. 1995 Nov;96(5):2170-9 PMID: 7593602
  43. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor.
    Science. 1996 Jan 26;271(5248):518-20 PMID: 8560269
  44. Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux.
    J Biol Chem. 1997 Aug 22;272(34):20982-5 PMID: 9261096
  45. The response-to-retention hypothesis of atherogenesis reinforced.
    Curr Opin Lipidol. 1998 Oct;9(5):471-4 PMID: 9812202
  46. Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.
    Biochem Biophys Res Commun. 1999 Apr 2;257(1):29-33 PMID: 10092505
  47. Cell cholesterol efflux: integration of old and new observations provides new insights.
    J Lipid Res. 1999 May;40(5):781-96 PMID: 10224147
  48. Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway.
    Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11358-63 PMID: 10500181
  49. Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages.
    Arterioscler Thromb Vasc Biol. 2002 Apr 1;22(4):630-7 PMID: 11950702
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
Published
2002-10-00
Pages
899-904
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC151157
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com