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PMID: 20848537 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The struggle within: microbial influences on colorectal cancer.

Inflammatory bowel diseases ·Vol. 17 ·No. 1 ·2011-01-00 ·Pages 396-409

Arthur JC, Jobin C

Abstract

Recently, an unprecedented effort has been directed at understanding the interplay between chronic inflammation and development of cancer, with the case of inflammatory bowel disease (IBD)-associated colorectal cancer at the forefront of this research endeavor. The last decade has been particularly fertile, with the discovery of numerous innovative paradigms linking various inflammatory, proliferative, and innate and adaptive immune signaling pathways to the development of colorectal cancer. Because of the preponderant role of the intestinal microbiota in the initiation and progression of IBD, recent efforts have been directed at understanding the relationship between bacteria and colorectal cancer. The microbiota and its collective genome, the microbiome, form a diverse and complex ecological community that profoundly impacts intestinal homeostasis and disease states. This review will discuss the differential influence of the microbiota on the development of IBD-associated colorectal cancer and highlight the role of innate immune sensor-dependent as well as -independent mechanisms in this pathology.

MeSH Terms
Bacteria/immunology Colorectal Neoplasms/etiology,pathology Humans Inflammatory Bowel Diseases/complications,microbiology Metagenome
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Arthur Janelle C
Department of Medicine and the Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina 27599-7080, USA.
Jobin Christian
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Article Info
Journal
Inflammatory bowel diseases
Abbr.
Inflamm Bowel Dis
ISSN
1536-4844
DOI
10.1002/ibd.21354
Published
2011-01-00
Pages
396-409
Language
English
Region
England
NLM ID
9508162
PMCID
PMC3376405
Subset
IM
Grants
NIDDK NIH HHS · R01 DK073338 · United States
NIDDK NIH HHS · R01 DK047700 · United States
NIDDK NIH HHS · T32DK007737 · United States
NIDDK NIH HHS · R56 DK047700 · United States
NIDDK NIH HHS · R01DK047700 · United States
NIDDK NIH HHS · R01DK073338 · United States
NIDDK NIH HHS · T32 DK007737 · United States
External Links
PubMed source DOI: 10.1002/ibd.21354 PMC Full Text View journal details
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