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PMID: 17933925 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Anaerobic metabolism of 1-amino-2-naphthol-based azo dyes (Sudan dyes) by human intestinal microflora.

Applied and environmental microbiology ·Vol. 73 ·No. 23 ·2007-12-00 ·Pages 7759-62

Xu H, Heinze TM, Chen S, Cerniglia CE, Chen H

Abstract

The rates of metabolism of Sudan I and II and Para Red by human intestinal microflora were high compared to those of Sudan III and IV under anaerobic conditions. Metabolites of the dyes were identified as aniline, 2,4-dimethylaniline, o-toluidine, and 4-nitroaniline through high-performance liquid chromatography and liquid chromatography electrospray ionization tandem mass spectrometry analyses. These data indicate that human intestinal bacteria are able to reduce Sudan dyes to form potentially carcinogenic aromatic amines.

MeSH Terms
Anaerobiosis Aniline Compounds/chemistry,metabolism Azo Compounds/chemistry,metabolism Bacteria/metabolism Chromatography, High Pressure Liquid Humans Intestines/microbiology Molecular Structure Naphthols/chemistry,metabolism Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry Toluidines/chemistry,metabolism
Chemicals
Aniline Compounds Azo Compounds Naphthols Toluidines 4-nitroaniline 2,4-xylidine 1-phenylazo-2-naphthol sudan red 2-toluidine 1-amino-2-naphthol sudan III aniline
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Xu Haiyan
Division of Microbiology, National Center for Toxicological Research, U.S. FDA, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA.
Heinze Thomas M
Chen Siwei
Cerniglia Carl E
Chen Huizhong
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Article Info
Journal
Applied and environmental microbiology
Abbr.
Appl Environ Microbiol
ISSN
1098-5336
DOI
10.1128/AEM.01410-07
Published
2007-12-00
Epub
2007-00-12
Pages
7759-62
Language
English
Region
United States
NLM ID
7605801
PMCID
PMC2168037
Subset
IM
External Links
PubMed source DOI: 10.1128/AEM.01410-07 PMC Full Text View journal details
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