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PMID: 20837780 Published · ppublish English Journal Article Research Support, N.I.H., Intramural

B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy.

Blood ·Vol. 116 ·No. 25 ·2010-12-16 ·Pages 5571-9

Moir S, Buckner CM, Ho J, Wang W, Chen J, Waldner AJ, Posada JG, Kardava L, O'Shea MA, Kottilil S, Chun TW, Proschan MA, Fauci AS

Abstract

Characterization of lymphocytes including B cells during early versus chronic HIV infection is important for understanding the impact of chronic viremia on immune cell function. In this setting, we investigated B cells before and after reduction of HIV plasma viremia by antiretroviral therapy (ART). At baseline, peripheral blood B-cell counts were significantly lower in both early and chronic HIV-infected individuals compared with uninfected controls. Similar to CD4(+) but not CD8(+) T cells, B-cell numbers in both groups increased significantly after ART. At baseline, B cells of early HIV-infected individuals were composed of a higher percentage of plasmablasts and resting memory B cells compared with chronic HIV-infected individuals whose B cells were composed of a higher percentage of immature/transitional and exhausted B cells compared with their early infection counterparts. At 1 year after ART, the percentage of resting memory B cells remained higher in early compared with chronic HIV-infected individuals. This difference translated into a better functional profile in that memory B-cell responses to HIV and non-HIV antigens were superior in early- compared with chronic-treated HIV infected individuals. These findings provide new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage.

MeSH Terms
Adult Antiretroviral Therapy, Highly Active B-Lymphocytes/immunology,virology CD4-Positive T-Lymphocytes/immunology,virology CD8-Positive T-Lymphocytes/immunology,virology Chronic Disease HIV Infections/drug therapy,immunology HIV-1/physiology Humans Immunologic Memory Lymphocyte Count Male Middle Aged Viral Load Viremia/immunology,virology Young Adult
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Moir Susan
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. smoir@niaid.nih.gov
Buckner Clarisa M
Ho Jason
Wang Wei
Chen Jenny
Waldner Amy J
Posada Jacqueline G
Kardava Lela
O'Shea Marie A
Kottilil Shyam
Chun Tae-Wook
Proschan Michael A
Fauci Anthony S
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Article Info
Journal
Blood
Abbr.
Blood
ISSN
1528-0020
DOI
10.1182/blood-2010-05-285528
Email
smoir@niaid.nih.gov
Published
2010-12-16
Epub
2010-00-13
Pages
5571-9
Language
English
Region
United States
NLM ID
7603509
PMCID
PMC3031405
Subset
IM
Grants
Intramural NIH HHS · United States
External Links
PubMed source DOI: 10.1182/blood-2010-05-285528 PMC Full Text View journal details
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