Home LiteratureArticle Details
PMID: 16461915 Published · ppublish English Journal Article Research Support, N.I.H., Intramural

Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 103 ·No. 7 ·2006-02-14 ·Pages 2262-7

Malaspina A, Moir S, Ho J, Wang W, Howell ML, O'Shea MA, Roby GA, Rehm CA, Mican JM, Chun TW, Fauci AS

Abstract

Progression of HIV disease is associated with the appearance of numerous B cell defects. We describe herein a population of immature/transitional B cells that is overly represented in the peripheral blood of individuals with advancing HIV disease. These B cells, identified by the expression of CD10, were unresponsive by proliferation to B cell receptor triggering and possessed a phenotype and an Ig diversity profile that confirmed their immature/transitional stage of differentiation. Consistent with an immature status, their lack of proliferation to B cell receptor triggering was reversed with CD40 ligand, but not B cell activation factor. Finally, levels of CD10 expression on B cells were directly correlated with serum levels of IL-7, suggesting that increased levels of IL-7 modulate human B cell maturation either directly or indirectly by means of a homeostatic effect on lymphopenia. Taken together, these data offer insight into human B cell development as well as B cell dysfunction in advanced HIV disease that may be linked to IL-7-dependent homeostatic events.

MeSH Terms
B-Lymphocytes/drug effects,immunology CD40 Ligand/pharmacology Cell Proliferation HIV Infections/immunology HIV-1 Humans Interleukin-7/blood,metabolism Lymphocyte Activation/immunology Lymphopenia/immunology Neprilysin/analysis Up-Regulation
Chemicals
Interleukin-7 CD40 Ligand Neprilysin
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Malaspina Angela
Laboratory of Immunoregulation, and Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Moir Susan
Ho Jason
Wang Wei
Howell Melissa L
O'Shea Marie A
Roby Gregg A
Rehm Catherine A
Mican Joann M
Chun Tae-Wook
Fauci Anthony S
References (33)
33 references, click to expand
  1. Loss of memory (CD27) B lymphocytes in HIV-1 infection.
    AIDS. 2001 May 25;15(8):957-64 PMID: 11399977
  2. A potential role for interleukin-7 in T-cell homeostasis.
    Blood. 2001 May 15;97(10):2983-90 PMID: 11342421
  3. Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjögren's syndrome.
    J Immunol. 2001 Oct 1;167(7):3610-8 PMID: 11564773
  4. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation.
    J Immunol. 2001 Dec 15;167(12):6834-40 PMID: 11739500
  5. CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause?
    Nat Med. 2002 Apr;8(4):319-23 PMID: 11927927
  6. B-cell activation and lymphoma in patients with HIV.
    Curr Opin Oncol. 2002 Sep;14(5):528-32 PMID: 12192272
  7. Turnover rates of B cells, T cells, and NK cells in simian immunodeficiency virus-infected and uninfected rhesus macaques.
    J Immunol. 2003 Mar 1;170(5):2479-87 PMID: 12594273
  8. Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function.
    J Immunol. 2003 Jun 15;170(12):5965-72 PMID: 12794123
  9. Predominant autoantibody production by early human B cell precursors.
    Science. 2003 Sep 5;301(5638):1374-7 PMID: 12920303
  10. Molecular mechanisms guiding late stages of B-cell development.
    Immunol Rev. 2004 Feb;197:41-50 PMID: 14962185
  11. Peripheral B-cell maturation: the intersection of selection and homeostasis.
    Immunol Rev. 2004 Feb;197:89-101 PMID: 14962189
  12. Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection.
    Blood. 2004 Mar 15;103(6):2180-6 PMID: 14604962
  13. Antigen receptor-mediated signaling pathways in transitional immature B cells.
    Cell Signal. 2004 Aug;16(8):881-9 PMID: 15157667
  14. Keeping track of pro-B cells: a new model for the effects of IL-7 during B cell development.
    Eur J Immunol. 2004 Oct;34(10):2642-6 PMID: 15368279
  15. Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily.
    J Exp Med. 2004 Oct 4;200(7):587-99 PMID: 15508184
  16. Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome.
    N Engl J Med. 1983 Aug 25;309(8):453-8 PMID: 6224088
  17. Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity.
    J Immunol. 1987 Jun 1;138(11):3720-4 PMID: 2953790
  18. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.
    Nature. 1991 Sep 12;353(6340):180-4 PMID: 1832488
  19. Striking inverse association of IgG-anti-Fab gamma antibodies and CD4 cell counts in patients with acquired immunodeficiency syndrome (AIDS)/AIDS-related complex.
    Blood. 1992 Feb 15;79(4):954-7 PMID: 1531308
  20. The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34.
    J Immunol. 1995 Jan 1;154(1):58-67 PMID: 7527823
  21. Lymphoproliferative disorders in IL-7 transgenic mice: expansion of immature B cells which retain macrophage potential.
    Int Immunol. 1995 Mar;7(3):415-23 PMID: 7794821
  22. Host factors and the pathogenesis of HIV-induced disease.
    Nature. 1996 Dec 12;384(6609):529-34 PMID: 8955267
  23. Clinical implications of autoantibodies in HIV infection.
    AIDS. 1997 Dec;11(15):1845-50 PMID: 9412703
  24. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter.
    Immunity. 1999 Mar;10(3):289-99 PMID: 10204485
  25. Compromised B cell responses to influenza vaccination in HIV-infected individuals.
    J Infect Dis. 2005 May 1;191(9):1442-50 PMID: 15809902
  26. Idiopathic CD4+ lymphocytopenia may be due to decreased bone marrow clonogenic capability.
    Int Arch Allergy Immunol. 2005 Apr;136(4):379-84 PMID: 15746558
  27. Identification and characterization of circulating human transitional B cells.
    Blood. 2005 Jun 1;105(11):4390-8 PMID: 15701725
  28. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance.
    J Immunol. 2005 Jun 1;174(11):6571-6 PMID: 15905493
  29. Fates of human B-cell precursors.
    Blood. 2000 Jul 1;96(1):9-23 PMID: 10891425
  30. Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency.
    J Immunol. 2000 Oct 15;165(8):4725-30 PMID: 11035117
  31. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis.
    Nat Med. 2001 Jan;7(1):73-9 PMID: 11135619
  32. Circulating human B cells that express surrogate light chains and edited receptors.
    Nat Immunol. 2000 Sep;1(3):207-13 PMID: 10973277
  33. HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals.
    Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10362-7 PMID: 11504927
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0511094103
Published
2006-02-14
Epub
2006-00-06
Pages
2262-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1413756
Subset
IM
Grants
Intramural NIH HHS · United States
External Links
PubMed source DOI: 10.1073/pnas.0511094103 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2