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PMID: 20594621 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.

Neurobiology of aging ·Vol. 33 ·No. 3 ·2012-03-00 ·Pages 437-56

Guerreiro RJ, Gustafson DR, Hardy J

Abstract

Alzheimer's disease (AD) is a complex disorder with a clear genetic component. Three genes have been identified as the cause of early onset familial AD (EOAD). The most common form of the disease, late onset Alzheimer's disease (LOAD), is, however, a sporadic one presenting itself in later stages of life. The genetic component of this late onset form of AD has been the target of a large number of studies, because only one genetic risk factor (APOE4) has been consistently associated with the disease. However, technological advances allow new approaches in the study of complex disorders. In this review, we discuss the new results produced by genome wide association studies, in light of the current knowledge of the complexity of AD genetics.

MeSH Terms
Alzheimer Disease/genetics,metabolism,pathology Amyloid beta-Protein Precursor/biosynthesis,chemistry,genetics Animals Apolipoproteins E/biosynthesis,chemistry,genetics Humans Presenilin-1/biosynthesis,chemistry,genetics Presenilin-2/biosynthesis,chemistry,genetics
Chemicals
Amyloid beta-Protein Precursor Apolipoproteins E PSEN1 protein, human PSEN2 protein, human Presenilin-1 Presenilin-2
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Guerreiro Rita J
Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, MD, USA. portalegrer@nia.nih.gov
Gustafson Deborah R
Hardy John
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Article Info
Journal
Neurobiology of aging
Abbr.
Neurobiol Aging
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2010.03.025
Email
portalegrer@nia.nih.gov
Published
2012-03-00
Epub
2010-00-01
Pages
437-56
Language
English
Region
United States
NLM ID
8100437
PMCID
PMC2980860
Subset
IM
Grants
Medical Research Council · MR/K01417X/1 · United Kingdom
Medical Research Council · G0701075 · United Kingdom
Medical Research Council · MC_G1000735 · United Kingdom
Intramural NIH HHS · Z01 AG000950 · United States
Wellcome Trust · 089698 · United Kingdom
Intramural NIH HHS · Z01 AG000950-06 · United States
NIA NIH HHS · Z01 AG000950-06 · United States
External Links
PubMed source DOI: 10.1016/j.neurobiolaging.2010.03.025 PMC Full Text View journal details
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