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PMID: 2780570 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Changes in brain gene expression shared by scrapie and Alzheimer disease.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 18 ·1989-09-00 ·Pages 7260-4

Duguid JR, Bohmont CW, Liu NG, Tourtellotte WW

Abstract

We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases.

MeSH Terms
Alzheimer Disease/genetics,metabolism Animals Base Sequence Brain/metabolism Clusterin Cricetinae Genes Glial Fibrillary Acidic Protein/genetics Glycoproteins/genetics Metallothionein/genetics Molecular Chaperones Molecular Sequence Data Nerve Tissue Proteins/genetics RNA, Messenger/genetics Rats Scrapie/genetics,metabolism Sequence Homology, Nucleic Acid Transcription, Genetic Transferrin/genetics
Chemicals
Clusterin Glial Fibrillary Acidic Protein Glycoproteins Molecular Chaperones Nerve Tissue Proteins RNA, Messenger Transferrin Metallothionein
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Duguid J R
Geriatric Research, Education and Clinical Center, Edith N. Rogers Memorial Veterans Hospital, Bedford, MA 01730.
Bohmont C W
Liu N G
Tourtellotte W W
References (30)
30 references, click to expand
  1. The molecular pathogenesis of astrogliosis in scrapie and Alzheimer's disease.
    Microb Pathog. 1987 Jun;2(6):435-42 PMID: 3507557
  2. Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library.
    Proc Natl Acad Sci U S A. 1988 Aug;85(15):5738-42 PMID: 2456582
  3. [Distribution of senile changes in the brain. The part of the limbic system in Alzheimer's disase and senile dementia].
    Arch Psychiatr Nervenkr (1970). 1968;211(3):308-24 PMID: 5704328
  4. Infectious etiology of neuritic (senile) plaques in mice.
    Science. 1975 Dec 12;190(4219):1108-10 PMID: 1237933
  5. Characteristics of a short incubation model of scrapie in the golden hamster.
    J Gen Virol. 1977 Feb;34(2):295-304 PMID: 402439
  6. Unconventional viruses and the origin and disappearance of kuru.
    Science. 1977 Sep 2;197(4307):943-60 PMID: 142303
  7. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  8. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
    Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5 PMID: 6159641
  9. Creutzfeldt-Jakob disease virus isolations from the Gerstmann-Sträussler syndrome with an analysis of the various forms of amyloid plaque deposition in the virus-induced spongiform encephalopathies.
    Brain. 1981 Sep;104(3):559-88 PMID: 6791762
  10. Novel proteinaceous infectious particles cause scrapie.
    Science. 1982 Apr 9;216(4542):136-44 PMID: 6801762
  11. Human metallothionein genes: molecular cloning and sequence analysis of the mRNA.
    Nucleic Acids Res. 1982 May 25;10(10):3165-73 PMID: 6896577
  12. Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.
    Proc Natl Acad Sci U S A. 1983 Jan;80(2):472-6 PMID: 6188151
  13. Chick embryo spinal cord neurons synthesize a transferrin-like myotrophic protein.
    FEBS Lett. 1983 Mar 21;153(2):387-90 PMID: 6617868
  14. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
    Anal Biochem. 1983 Jul 1;132(1):6-13 PMID: 6312838
  15. A method for isolation of intact, translationally active ribonucleic acid.
    DNA. 1983;2(4):329-35 PMID: 6198133
  16. Molecular cloning and sequence analysis of cDNA for human transferrin.
    Biochem Biophys Res Commun. 1984 Feb 29;119(1):273-81 PMID: 6322780
  17. Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments.
    Proc Natl Acad Sci U S A. 1984 May;81(9):2743-6 PMID: 6585825
  18. Sharing of specific antigens by degenerating neurons in Pick's disease and Alzheimer's disease.
    N Engl J Med. 1985 Mar 14;312(11):700-5 PMID: 2579334
  19. The National Neurological Research Bank. A collection of cryopreserved human neurological specimens for neuroscientists.
    Ann N Y Acad Sci. 1984;436:513-6 PMID: 6598028
  20. Amyloid plaque core protein in Alzheimer disease and Down syndrome.
    Proc Natl Acad Sci U S A. 1985 Jun;82(12):4245-9 PMID: 3159021
  21. Nature of the scrapie agent: current status of facts and hypotheses.
    J Gen Virol. 1985 Jul;66 ( Pt 7):1357-68 PMID: 3926950
  22. Transferrin gene expression visualized in oligodendrocytes of the rat brain by using in situ hybridization and immunohistochemistry.
    Proc Natl Acad Sci U S A. 1985 Oct;82(19):6706-10 PMID: 3901006
  23. High cerebrospinal fluid concentration of glial fibrillary acidic protein (GFAP) in patients with normal pressure hydrocephalus.
    J Neurol Sci. 1985 Oct;70(3):269-74 PMID: 4056822
  24. Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related.
    Proc Natl Acad Sci U S A. 1985 Dec;82(24):8729-32 PMID: 2934737
  25. Increased GFAp levels in CSF as a marker of organicity in patients with Alzheimer's disease and other types of irreversible chronic organic brain syndrome.
    J Neurol. 1986 Jun;233(3):157-60 PMID: 3522811
  26. Transferrin messenger ribonucleic acid: molecular cloning and hormonal regulation in rat Sertoli cells.
    Endocrinology. 1987 Jan;120(1):332-40 PMID: 3023031
  27. Prions causing degenerative neurological diseases.
    Annu Rev Med. 1987;38:381-98 PMID: 3555303
  28. Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells.
    Biochemistry. 1987 Jun 16;26(12):3297-303 PMID: 3651384
  29. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease.
    Cell. 1988 Feb 26;52(4):487-501 PMID: 3257719
  30. Cloning of a gene whose expression is increased in scrapie and in senile plaques in human brain.
    Science. 1985 Dec 6;230(4730):1177-9 PMID: 3840915
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.18.7260
Published
1989-09-00
Pages
7260-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC298037
Subset
IM
Grants
NIA NIH HHS · R01 AG05894-16 · United States
Databases
GENBANK
M26637, M26638, M26639, M26640, M26641, M26642
External Links
PubMed source DOI: 10.1073/pnas.86.18.7260 PMC Full Text View journal details
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