MeSH Terms
ATP Binding Cassette Transporter 1
ATP-Binding Cassette Transporters/genetics
Animals
Cholesterol/biosynthesis,metabolism
Gene Expression Regulation
Humans
Hyperinsulinism/genetics,metabolism
Introns
Lipoproteins, HDL/blood
Liver/metabolism
Metabolic Syndrome/genetics,metabolism
MicroRNAs/antagonists & inhibitors,genetics,metabolism
RNA, Messenger/genetics,metabolism
Sterol Regulatory Element Binding Protein 1/genetics,metabolism
Sterol Regulatory Element Binding Protein 2/genetics,metabolism
Transcription, Genetic
Chemicals
ATP Binding Cassette Transporter 1
ATP-Binding Cassette Transporters
Lipoproteins, HDL
MicroRNAs
RNA, Messenger
Sterol Regulatory Element Binding Protein 1
Sterol Regulatory Element Binding Protein 2
Cholesterol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Brown Michael S
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. mike.brown@utsouthwestern.edu
Ye Jin
Goldstein Joseph L
References (11)
11 references, click to expand
-
Why Syndrome X? From Harold Himsworth to the insulin resistance syndrome.
Cell Metab. 2005 Jan;1(1):9-14
PMID: 16054040
-
Mouse models of the metabolic syndrome.
Dis Model Mech. 2010 Mar-Apr;3(3-4):156-66
PMID: 20212084
-
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11245-50
PMID: 15266058
-
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.
Cell. 1997 May 2;89(3):331-40
PMID: 9150132
-
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.
J Clin Invest. 1997 Mar 1;99(5):838-45
PMID: 9062340
-
MiR-33 contributes to the regulation of cholesterol homeostasis.
Science. 2010 Jun 18;328(5985):1570-3
PMID: 20466885
-
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
J Clin Invest. 2002 May;109(9):1125-31
PMID: 11994399
-
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
Genes Dev. 2000 Nov 15;14(22):2819-30
PMID: 11090130
-
Fatty acid auxotrophy in Drosophila larvae lacking SREBP.
Cell Metab. 2006 Jun;3(6):439-48
PMID: 16753579
-
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.
Science. 2010 Jun 18;328(5985):1566-9
PMID: 20466882
-
ABCA1: at the nexus of cholesterol, HDL and atherosclerosis.
Trends Biochem Sci. 2007 Apr;32(4):172-9
PMID: 17324574