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PMID: 20484389 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Gene positioning.

Cold Spring Harbor perspectives in biology ·Vol. 2 ·No. 6 ·2010-06-00 ·Pages a000588

Ferrai C, de Castro IJ, Lavitas L, Chotalia M, Pombo A

Abstract

Eukaryotic gene expression is an intricate multistep process, regulated within the cell nucleus through the activation or repression of RNA synthesis, processing, cytoplasmic export, and translation into protein. The major regulators of gene expression are chromatin remodeling and transcription machineries that are locally recruited to genes. However, enzymatic activities that act on genes are not ubiquitously distributed throughout the nucleoplasm, but limited to specific and spatially defined foci that promote preferred higher-order chromatin arrangements. The positioning of genes within the nuclear landscape relative to specific functional landmarks plays an important role in gene regulation and disease.

MeSH Terms
Chromatin/genetics Gene Expression Regulation/physiology Gene Order/genetics,physiology Genetic Diseases, Inborn/genetics Genetic Predisposition to Disease
Chemicals
Chromatin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ferrai Carmelo
Genome Function Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London, United Kingdom.
de Castro Inês Jesus
Lavitas Liron
Chotalia Mita
Pombo Ana
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a000588
Published
2010-06-00
Epub
2010-00-19
Pages
a000588
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC2869523
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · BB/H008098/1 · United Kingdom
Medical Research Council · MC_U120061476 · United Kingdom
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1101/cshperspect.a000588 PMC Full Text View journal details
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