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PMID: 20440748 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Translation initiation of viral mRNAs.

Reviews in medical virology ·Vol. 20 ·No. 3 ·2010-05-00 ·Pages 177-95

López-Lastra M, Ramdohr P, Letelier A, Vallejos M, Vera-Otarola J, Valiente-Echeverría F

Abstract

Viruses depend on cells for their replication but have evolved mechanisms to achieve this in an efficient and, in some instances, a cell-type-specific manner. The expression of viral proteins is frequently subject to translational control. The dominant target of such control is the initiation step of protein synthesis. Indeed, during the early stages of infection, viral mRNAs must compete with their host counterparts for the protein synthetic machinery, especially for the limited pool of eukaryotic translation initiation factors (eIFs) that mediate the recruitment of ribosomes to both viral and cellular mRNAs. To circumvent this competition viruses use diverse strategies so that ribosomes can be recruited selectively to viral mRNAs. In this review we focus on the initiation of protein synthesis and outline some of the strategies used by viruses to ensure efficient translation initiation of their mRNAs.

MeSH Terms
Peptide Chain Initiation, Translational RNA, Messenger/genetics,metabolism RNA, Viral/genetics,metabolism Ribosomes/metabolism Virus Physiological Phenomena
Chemicals
RNA, Messenger RNA, Viral
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
López-Lastra Marcelo
Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 391, Santiago, Chile. malopez@med.puc.cl
Ramdohr Pablo
Letelier Alejandro
Vallejos Maricarmen
Vera-Otarola Jorge
Valiente-Echeverría Fernando
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Article Info
Journal
Reviews in medical virology
Abbr.
Rev Med Virol
ISSN
1099-1654
DOI
10.1002/rmv.649
Email
malopez@med.puc.cl
Published
2010-05-00
Pages
177-95
Language
English
Region
England
NLM ID
9112448
PMCID
PMC7169124
Subset
IM
External Links
PubMed source DOI: 10.1002/rmv.649 PMC Full Text View journal details
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