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PMID: 20371343 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Review

Origin of chromosomal translocations in lymphoid cancer.

Cell ·Vol. 141 ·No. 1 ·2010-04-02 ·Pages 27-38

Nussenzweig A, Nussenzweig MC

Abstract

Aberrant fusions between heterologous chromosomes are among the most prevalent cytogenetic abnormalities found in cancer cells. Oncogenic chromosomal translocations provide cells with a proliferative or survival advantage. They may either initiate transformation or be acquired secondarily as a result of genomic instability. Here, we highlight recent advances toward understanding the origin of chromosomal translocations in incipient lymphoid cancers and how tumor-suppressive pathways normally limit the frequency of these aberrant recombination events. Deciphering the mechanisms that mediate chromosomal fusions will open new avenues for developing therapeutic strategies aimed at eliminating lesions that lead to the initiation, maintenance, and progression of cancer.

MeSH Terms
Humans Lymphoma/drug therapy,genetics,metabolism Translocation, Genetic Tumor Suppressor Proteins/metabolism
Chemicals
Tumor Suppressor Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nussenzweig André
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. andre_nussenzweig@nih.gov
Nussenzweig Michel C
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2010.03.016
Email
andre_nussenzweig@nih.gov
Published
2010-04-02
Pages
27-38
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC2874895
Subset
IM
Grants
NIAID NIH HHS · R01 AI037526 · United States
Intramural NIH HHS · ZIA BC010283-08 · United States
Intramural NIH HHS · Z99 CA999999 · United States
Intramural NIH HHS · Z01 BC010959-01 · United States
Howard Hughes Medical Institute · United States
Intramural NIH HHS · Z01 BC010283-11 · United States
NIAID NIH HHS · AI037526 · United States
NIAID NIH HHS · R37 AI037526 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2010.03.016 PMC Full Text View journal details
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