Home LiteratureArticle Details
PMID: 18180452 Published · ppublish English Journal Article Comment

Alternative endings.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 105 ·No. 2 ·2008-01-15 ·Pages 405-6

Haber JE

Abstract

暂无摘要

MeSH Terms
Animals Antigens, Nuclear/genetics,physiology CD4-Positive T-Lymphocytes/metabolism DNA Damage DNA Repair DNA-Binding Proteins/genetics,physiology Gene Expression Regulation Genetic Complementation Test Ku Autoantigen Mice Mice, Transgenic Models, Genetic Phenotype
Chemicals
Antigens, Nuclear DNA-Binding Proteins XRCC4 protein, mouse Xrcc6 protein, mouse Ku Autoantigen
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Haber James E
Department of Biology and Rosenstiel Center, Brandeis University, Waltham, MA 02454-9110, USA. haber@brandeis.edu
References (20)
20 references, click to expand
  1. Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells.
    Eur J Immunol. 2002 Mar;32(3):701-9 PMID: 11870614
  2. Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends.
    Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20902-7 PMID: 18093953
  3. The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants.
    DNA Repair (Amst). 2002 Dec 5;1(12):1017-26 PMID: 12531011
  4. Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences.
    Mol Cell Biol. 2003 Dec;23(23):8820-8 PMID: 14612421
  5. ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.
    Mol Cell. 2003 Dec;12(6):1489-98 PMID: 14690602
  6. Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells.
    Mol Cell. 2004 Jun 4;14(5):611-23 PMID: 15175156
  7. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV.
    Nature. 1998 Nov 12;396(6707):173-7 PMID: 9823897
  8. Double-strand break repair in Ku86- and XRCC4-deficient cells.
    Nucleic Acids Res. 1998 Dec 1;26(23):5333-42 PMID: 9826756
  9. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.
    Cell. 1998 Dec 23;95(7):891-902 PMID: 9875844
  10. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice.
    Curr Biol. 1998 Dec 17-31;8(25):1395-8 PMID: 9889105
  11. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.
    Curr Biol. 1999 Jul 1;9(13):699-702 PMID: 10395545
  12. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining.
    Cancer Res. 2005 May 15;65(10):4020-30 PMID: 15899791
  13. Nonhomologous end joining in yeast.
    Annu Rev Genet. 2005;39:431-51 PMID: 16285867
  14. The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells.
    Nucleic Acids Res. 2006;34(10):2998-3007 PMID: 16738138
  15. Role of non-homologous end joining (NHEJ) in maintaining genomic integrity.
    DNA Repair (Amst). 2006 Sep 8;5(9-10):1042-8 PMID: 16822724
  16. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.
    Nucleic Acids Res. 2006;34(21):6170-82 PMID: 17088286
  17. Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells.
    Nucleic Acids Res. 2007;35(11):3551-60 PMID: 17483519
  18. Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.
    J Exp Med. 2007 Jul 9;204(7):1717-27 PMID: 17606631
  19. IgH class switching and translocations use a robust non-classical end-joining pathway.
    Nature. 2007 Sep 27;449(7161):478-82 PMID: 17713479
  20. Rag mutations reveal robust alternative end joining.
    Nature. 2007 Sep 27;449(7161):483-6 PMID: 17898768
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.0711334105
Email
haber@brandeis.edu
Published
2008-01-15
Epub
2008-00-07
Pages
405-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC2206546
Subset
IM
Grants
NIGMS NIH HHS · R01 GM076020 · United States
NIGMS NIH HHS · R01 GM020056-33 · United States
NIGMS NIH HHS · R01 GM076020-03 · United States
NIGMS NIH HHS · R01 GM061766 · United States
NIGMS NIH HHS · R01 GM020056 · United States
NIGMS NIH HHS · R01 GM061766-08 · United States
Corrections
CommentOn
PMID: 18093953
External Links
PubMed source DOI: 10.1073/pnas.0711334105 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2