RAGs and regulation of autoantibodies.

Annual review of immunology ·Vol. 22 ·2004-00-00 ·Pages 485-501

Jankovic M, Casellas R, Yannoutsos N, Wardemann H, Nussenzweig MC

Abstract

Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG1 and RAG2) in this process.

MeSH Terms

Animals Antibody Formation/genetics Autoantibodies/genetics B-Lymphocytes/immunology DNA-Binding Proteins/genetics,immunology Gene Rearrangement, B-Lymphocyte Genes, Immunoglobulin Homeodomain Proteins/genetics,immunology Humans Immunoglobulin Variable Region/genetics Nuclear Proteins

Chemicals

Autoantibodies DNA-Binding Proteins Homeodomain Proteins Immunoglobulin Variable Region Nuclear Proteins RAG2 protein, human V(D)J recombination activating protein 2 RAG-1 protein

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Jankovic Mila

Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10021, USA. jankovm@mail.rockefeller.edu

Casellas Rafael

Yannoutsos Nikos

Wardemann Hedda

Nussenzweig Michel C

Article Info

Journal

Annual review of immunology

Abbr.

Annu Rev Immunol

ISSN

0732-0582

DOI

10.1146/annurev.immunol.22.012703.104707

jankovm@mail.rockefeller.edu

Published

2004-00-00

Pages

485-501

Language

English

Region

United States

NLM ID

8309206

Subset

External Links

PubMed source DOI: 10.1146/annurev.immunol.22.012703.104707 View journal details

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