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PMID: 20051982 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

MicroRNA assassins: factors that regulate the disappearance of miRNAs.

Nature structural & molecular biology ·Vol. 17 ·No. 1 ·2010-01-00 ·Pages 5-10

Kai ZS, Pasquinelli AE

Abstract

MicroRNAs (miRNAs) control essential gene regulatory pathways in plants and animals. Serving as guides in silencing complexes, miRNAs direct Argonaute proteins to specific target messenger RNAs to repress protein expression. The mature, 22-nucleotide (nt) miRNA is the product of multiple processing steps, and recent studies have uncovered factors that directly control the stability of the functional RNA form. Although alteration of miRNA levels has been linked to numerous disease states, the mechanisms responsible for stabilized or reduced miRNA expression have been largely elusive. The discovery of specific cis-acting modifications and trans-acting proteins that affect miRNA half-life reveals new elements that contribute to the homeostasis of these vital regulatory molecules.

MeSH Terms
Eukaryotic Initiation Factors/metabolism Exoribonucleases/metabolism Gene Expression Regulation/genetics Gene Regulatory Networks/genetics Karyopherins/metabolism MicroRNAs/biosynthesis,metabolism Models, Molecular Ribonuclease III/metabolism
Chemicals
Eukaryotic Initiation Factors Karyopherins MicroRNAs Exoribonucleases Ribonuclease III
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kai Zoya S
Department of Biology, University of California, San Diego, La Jolla, California, USA.
Pasquinelli Amy E
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Article Info
Journal
Nature structural & molecular biology
Abbr.
Nat Struct Mol Biol
ISSN
1545-9985
DOI
10.1038/nsmb.1762
Published
2010-01-00
Pages
5-10
Language
English
Region
United States
NLM ID
101186374
PMCID
PMC6417416
Subset
IM
Grants
NIGMS NIH HHS · R01 GM071654 · United States
NIGMS NIH HHS · R01 GM071654-07 · United States
NIGMS NIH HHS · GM071654-01 · United States
External Links
PubMed source DOI: 10.1038/nsmb.1762 PMC Full Text View journal details
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