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PMID: 19672277 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.

Nature reviews. Molecular cell biology ·Vol. 10 ·No. 9 ·2009-09-00 ·Pages 623-35

Saftig P, Klumperman J

Abstract

Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade extracellular material that has been internalized by endocytosis and intracellular components that have been sequestered by autophagy. In addition, specialized cells contain lysosome-related organelles that store and secrete proteins for cell-type-specific functions. The functioning of a healthy cell is dependent on the proper targeting of newly synthesized lysosomal proteins. Accumulating evidence suggests that there are multiple lysosomal delivery pathways that together allow the regulated and sequential deposition of lysosomal components. The importance of lysosomal trafficking pathways is emphasized by recent findings that reveal new roles for lysosomal membrane proteins in cellular physiology and in an increasing number of diseases that are characterized by defects in lysosome biogenesis.

MeSH Terms
Animals Endocytosis/physiology Humans Lysosomes/physiology Membrane Proteins/metabolism Organelle Biogenesis Phagocytosis Proteins/metabolism
Chemicals
Membrane Proteins Proteins lysosomal proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Saftig Paul
Department of Biochemistry, Christian-Albrechts University, Kiel, Germany. psaftig@biochem.uni-kiel.de
Klumperman Judith
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2745
Email
psaftig@biochem.uni-kiel.de
Published
2009-09-00
Epub
2009-00-12
Pages
623-35
Language
English
Region
England
NLM ID
100962782
Subset
IM
External Links
PubMed source DOI: 10.1038/nrm2745 View journal details
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