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PMID: 1946441 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Evolution of gene position: chromosomal arrangement and sequence comparison of the Drosophila melanogaster and Drosophila virilis sina and Rh4 genes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 22 ·1991-11-15 ·Pages 10203-7

Neufeld TP, Carthew RW, Rubin GM

Abstract

The seven in absentia (sina) gene of Drosophila encodes a nuclear protein required for normal eye development. In Drosophila melanogaster, the sina gene is located within an intron of the Rh4 opsin gene. We examine here the nucleotide sequences and chromosomal arrangements of these genes in Drosophila virilis. An interspecies comparison between D. melanogaster and D. virilis reveals that the protein-coding sequences of the sina and Rh4 genes are highly conserved, but the relative chromosomal position and structural arrangement of these genes differ between the two species. In particular, the sina and Rh4 genes are widely separated in D. virilis, and there is no intron in the Rh4 gene. Our results suggest that the Rh4 gene was translocated to another chromosomal location by a retrotransposition event.

Related Genes

Rh4 sina

MeSH Terms

Animals Base Sequence Biological Evolution Chromosome Mapping Cloning, Molecular DNA Probes Drosophila/genetics Drosophila melanogaster/genetics Genomic Library Molecular Sequence Data Nucleic Acid Hybridization Restriction Mapping Salivary Glands/physiology Sequence Homology, Nucleic Acid

Chemicals

DNA Probes

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Neufeld T P

Howard Hughes Medical Institute, University of California, Berkeley 94720.

Carthew R W

Rubin G M

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.88.22.10203

Published

1991-11-15

Pages

10203-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC52896

Subset

Databases

GENBANK

M77281, M77282, M80719, M80720, M80721, M80722, M80723, M80724, S66723, S66727

External Links

PubMed source DOI: 10.1073/pnas.88.22.10203 PMC Full Text View journal details

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Evolution of gene position: chromosomal arrangement and sequence comparison of the Drosophila melanogaster and Drosophila virilis sina and Rh4 genes.

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