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PMID: 2823118 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon.

Molecular and cellular biology ·Vol. 7 ·No. 9 ·1987-09-00 ·Pages 3107-12

Boer PH, Adra CN, Lau YF, McBurney MW

Abstract

In both humans and mice, two genes encode phosphoglycerate kinase, a key enzyme in the glycolytic pathway. The pgk-1 gene is expressed in all somatic cells, is located on the X chromosome, and contains 10 introns. The pgk-2 gene is expressed only in sperm cells, is located on an autosome, and has no introns. The nucleotide sequence of the pgk-2 gene suggests that it arose from pgk-1 more than 100 million years ago by RNA-mediated gene duplication. The pgk-2 gene may, then, be a transcribed retroposon. Thus, gene duplication by retroposition may have been used as a mechanism for evolutionary diversification.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Chromosome Mapping DNA/genetics DNA Restriction Enzymes Gene Expression Regulation Genes Male Mice Molecular Sequence Data Phosphoglycerate Kinase/genetics RNA, Messenger/genetics Testis/enzymology,physiology Transcription, Genetic
Chemicals
RNA, Messenger DNA Phosphoglycerate Kinase DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Boer P H
Department of Medicine, University of Ottawa, Canada.
Adra C N
Lau Y F
McBurney M W
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.7.9.3107-3112.1987
Published
1987-09-00
Pages
3107-12
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC367943
Subset
IM
Databases
GENBANK
M17299, M18654
External Links
PubMed source DOI: 10.1128/mcb.7.9.3107-3112.1987 PMC Full Text View journal details
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