Home LiteratureArticle Details
PMID: 19330028 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.

Nature genetics ·Vol. 41 ·No. 5 ·2009-05-00 ·Pages 518-20

Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo AA, Fetsch P, Filie AC, O'Connell MP, Banister CE, Howard JD, Buckhaults P, Weeraratna AT, Brody LC, Rosenberg SA, Samuels Y

Abstract

A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.

MeSH Terms
Chromosomal Instability Glaucoma/congenital Glioma/genetics,metabolism Humans Matrix Metalloproteinase 8/genetics,metabolism Melanoma/enzymology,genetics,metabolism Mutation
Chemicals
Matrix Metalloproteinase 8
Authors & Affiliations
24 authors, click to expand affiliations / ORCID
Palavalli Lavanya H
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Prickett Todd D
Wunderlich John R
Wei Xiaomu
Burrell Allison S
Porter-Gill Patricia
Davis Sean
Wang Chenwei
Cronin Julia C
Agrawal Neena S
Lin Jimmy C
Westbroek Wendy
Hoogstraten-Miller Shelley
Molinolo Alfredo A
Fetsch Patricia
Filie Armando C
O'Connell Michael P
Banister Carolyn E
Howard Jason D
Buckhaults Phillip
Weeraratna Ashani T
Brody Lawrence C
Rosenberg Steven A
Samuels Yardena
References (14)
14 references, click to expand
  1. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.
    Nat Genet. 2003 Nov;35(3):252-7 PMID: 14517555
  2. The melanocyte differentiation program predisposes to metastasis after neoplastic transformation.
    Nat Genet. 2005 Oct;37(10):1047-54 PMID: 16142232
  3. Matrix metalloproteinases and tumor progression.
    Adv Exp Med Biol. 2003;532:91-107 PMID: 12908552
  4. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer.
    Cancer Res. 2006 Aug 15;66(16):7968-75 PMID: 16912171
  5. Matrix metalloproteinases: a tail of a frog that became a prince.
    Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14 PMID: 11994741
  6. Matrix metalloproteinase inhibitors and cancer: trials and tribulations.
    Science. 2002 Mar 29;295(5564):2387-92 PMID: 11923519
  7. The consensus coding sequences of human breast and colorectal cancers.
    Science. 2006 Oct 13;314(5797):268-74 PMID: 16959974
  8. Mouse macrophage metalloelastase gene transfer into a murine melanoma suppresses primary tumor growth by halting angiogenesis.
    Clin Cancer Res. 2000 May;6(5):1647-54 PMID: 10815882
  9. Emerging roles of proteases in tumour suppression.
    Nat Rev Cancer. 2007 Oct;7(10):800-8 PMID: 17851543
  10. Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
    Cancer Res. 2008 Apr 15;68(8):2755-63 PMID: 18413742
  11. Patterns of somatic mutation in human cancer genomes.
    Nature. 2007 Mar 8;446(7132):153-8 PMID: 17344846
  12. Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression.
    Cancer Res. 2004 Mar 1;64(5):1687-94 PMID: 14996728
  13. New functions for the matrix metalloproteinases in cancer progression.
    Nat Rev Cancer. 2002 Mar;2(3):161-74 PMID: 11990853
  14. p53: puzzle and paradigm.
    Genes Dev. 1996 May 1;10(9):1054-72 PMID: 8654922
Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
DOI
10.1038/ng.340
Published
2009-05-00
Epub
2009-00-29
Pages
518-20
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC2748394
Subset
IM
Grants
Intramural NIH HHS · Z01 HG200337-01 · United States
Intramural NIH HHS · Z99 HG999999 · United States
External Links
PubMed source DOI: 10.1038/ng.340 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2