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PMID: 17851543 Published · ppublish English Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Emerging roles of proteases in tumour suppression.

Nature reviews. Cancer ·Vol. 7 ·No. 10 ·2007-00-00 ·Pages 800-8

López-Otín C, Matrisian LM

Abstract

Proteases have long been associated with cancer progression because of their ability to degrade extracellular matrices, which facilitates invasion and metastasis. However, recent studies have shown that these enzymes target a diversity of substrates and favour all steps of tumour evolution. Unexpectedly, the post-trial studies have also revealed proteases with tumour-suppressive effects. These effects are associated with more than 30 different enzymes that belong to three distinct protease classes. What are the clinical implications of these findings?

MeSH Terms
ADAM Proteins/metabolism Animals Antineoplastic Agents/administration & dosage Caspases/metabolism Cathepsins/metabolism Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/metabolism Disease Models, Animal Disease Progression Drug Delivery Systems/methods GPI-Linked Proteins Humans Kallikreins/metabolism Matrix Metalloproteinases/metabolism Membrane Proteins/metabolism Mice Neoplasms/drug therapy,enzymology Neprilysin/metabolism Peptide Hydrolases/classification,metabolism Serine Endopeptidases/metabolism Ubiquitin/metabolism
Chemicals
Antineoplastic Agents GPI-Linked Proteins Membrane Proteins Ubiquitin Cathepsins Peptide Hydrolases Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Kallikreins PRSS21 protein, human Serine Endopeptidases prostasin Caspases ADAM Proteins Matrix Metalloproteinases Neprilysin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
López-Otín Carlos
Carlos López-Otín is at the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain. CLO@uniovi.es
Matrisian Lynn M
Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc2228
Email
clo@uniovi.es
Published
2007-00-00
Pages
800-8
Language
English
Region
England
NLM ID
101124168
Subset
IM
External Links
PubMed source DOI: 10.1038/nrc2228 View journal details
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