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PMID: 19290475 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Cohesins: chromatin architects in chromosome segregation, control of gene expression and much more.

Cellular and molecular life sciences : CMLS ·Vol. 66 ·No. 13 ·2009-07-00 ·Pages 2025-35

Barbero JL

Abstract

Cells have evolved to develop molecules and control mechanisms that guarantee correct chromosome segregation and ensure the proper distribution of genetic material to daughter cells. In this sense, the establishment, maintenance, and removal of sister chromatid cohesion is one of the most fascinating and dangerous processes in the life of a cell because errors in the control of these processes frequently lead to cell death or aneuploidy. The main protagonist in this mechanism is a four-protein complex denominated the cohesin complex. In the last 10 years, we have improved our understanding of the key players in the regulation of sister chromatid cohesion during cell division in mitosis and meiosis. The last 2 years have seen an increase in evidence showing that cohesins have important functions in non-dividing cells, revealing new, unexplored roles for these proteins in the control of gene expression, development, and other essential cell functions in mammals.

MeSH Terms
Animals Cell Cycle Proteins/genetics,metabolism Centromere/metabolism Chromosomal Proteins, Non-Histone/genetics,metabolism Chromosome Segregation Gene Expression Regulation Humans Mitosis/physiology Models, Molecular Neurons/physiology Telomere/metabolism Transcription, Genetic
Chemicals
Cell Cycle Proteins Chromosomal Proteins, Non-Histone cohesins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Barbero José L
Departamento de Biología Celular y del Desarrollo, Centro de Investigaciones Biológicas (CSIC), C/Ramiro de Maeztu 9, 28040, Madrid, Spain. jlbarbero@cib.csic.es
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-9071
DOI
10.1007/s00018-009-0004-8
Email
jlbarbero@cib.csic.es
Published
2009-07-00
Epub
2009-00-17
Pages
2025-35
Language
English
Region
Switzerland
NLM ID
9705402
Subset
IM
External Links
PubMed source DOI: 10.1007/s00018-009-0004-8 View journal details
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