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PMID: 19197329 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Environmental sensing through focal adhesions.

Nature reviews. Molecular cell biology ·Vol. 10 ·No. 1 ·2009-01-00 ·Pages 21-33

Geiger B, Spatz JP, Bershadsky AD

Abstract

Recent progress in the design and application of artificial cellular microenvironments and nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal organization, and hence their shape and motility, to minute changes in their immediate surroundings. Integrin-based adhesion complexes, which are tightly associated with the actin cytoskeleton, comprise the cellular machinery that recognizes not only the biochemical diversity of the extracellular neighbourhood, but also its physical and topographical characteristics, such as pliability, dimensionality and ligand spacing. Here, we discuss the mechanisms of such environmental sensing, based on the finely tuned crosstalk between the assembly of one type of integrin-based adhesion complex, namely focal adhesions, and the forces that are at work in the associated cytoskeletal network owing to actin polymerization and actomyosin contraction.

MeSH Terms
Actins/metabolism Animals Cytoskeleton/physiology Environment Focal Adhesions/physiology Humans Integrins/metabolism Signal Transduction
Chemicals
Actins Integrins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Geiger Benjamin
Weizmann Institute of Science, Rehovot 76100, Israel. benny.geiger@weizmann.ac.il
Spatz Joachim P
Bershadsky Alexander D
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2593
Email
benny.geiger@weizmann.ac.il
Published
2009-01-00
Pages
21-33
Language
English
Region
England
NLM ID
100962782
Subset
IM
External Links
PubMed source DOI: 10.1038/nrm2593 View journal details
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