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PMID: 19197064 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.

Science (New York, N.Y.) ·Vol. 323 ·No. 5915 ·2009-02-06 ·Pages 779-82

Tang S, Presgraves DC

Abstract

Speciation often involves the evolution of incompatible gene interactions that cause sterility or lethality in hybrids between populations. These so-called hybrid incompatibilities occur between two or more functionally divergent loci. We show that the nucleoporin 160kDa (Nup160) gene of the fruitfly Drosophila simulans is incompatible with one or more factors on the D. melanogaster X chromosome, causing hybrid lethality. Nup160 encodes a nuclear pore complex protein and shows evidence of adaptive evolution. Furthermore, the protein encoded by Nup160 directly interacts with that of another hybrid lethality gene, Nup96, indicating that at least two lethal hybrid incompatibility genes have evolved as byproducts of divergent coevolution among interacting components of the Drosophila nuclear pore complex.

MeSH Terms
Animals Chromosome Mapping Crosses, Genetic Drosophila/genetics,physiology Drosophila Proteins/genetics,metabolism Drosophila melanogaster/genetics,physiology Evolution, Molecular Female Genes, Insect Genetic Speciation Hybridization, Genetic Male Molecular Sequence Data Mutation Nuclear Pore Complex Proteins/genetics,metabolism Selection, Genetic X Chromosome/genetics
Chemicals
Drosophila Proteins Nuclear Pore Complex Proteins nuclear pore complex protein 96
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tang Shanwu
Department of Biology, University of Rochester, Rochester, NY 14627, USA.
Presgraves Daven C
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1169123
Published
2009-02-06
Pages
779-82
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2826207
Subset
IM
Grants
NIGMS NIH HHS · R01 GM079543 · United States
NIGMS NIH HHS · R01 GM079543-01A1 · United States
NIGMS NIH HHS · R01-GM079543 · United States
Databases
GENBANK
FJ600378, FJ600379, FJ600380, FJ600381, FJ600382, FJ600383, FJ600384, FJ600385, FJ600386, FJ600387, FJ600388, FJ600389, FJ600390, FJ600391, FJ600392, FJ600393, FJ600394, FJ600395, FJ600396, FJ600397, FJ600398, FJ600399, FJ600400, FJ600401
External Links
PubMed source DOI: 10.1126/science.1169123 PMC Full Text View journal details
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