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PMID: 2797166 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus.

Nature ·Vol. 341 ·No. 6241 ·1989-10-05 ·Pages 415-21

Wittbrodt J, Adam D, Malitschek B, Mäueler W, Raulf F, Telling A, Robertson SM, Schartl M

Abstract

Malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu. By combining genetic and molecular approaches, we have isolated the melanoma oncogene. We show that its level of expression correlates with the degree of malignancy of the tumour. The corresponding proto-oncogene is developmentally regulated. The Tu gene codes for a novel receptor tyrosine kinase which is closely related to the receptor for epidermal growth factor.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Chromosome Mapping ErbB Receptors/genetics Fish Diseases/enzymology,genetics Fishes Gene Expression Genes Genes, Dominant Genetic Markers/analysis Melanoma/enzymology,genetics,veterinary Molecular Sequence Data Oncogenes Protein-Tyrosine Kinases/genetics Restriction Mapping

Chemicals

Genetic Markers ErbB Receptors Protein-Tyrosine Kinases

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Wittbrodt J

Genzentrum, Max-Planck-Institut für Biochemie, Martinsried, FRG.

Adam D

Malitschek B

Mäueler W

Raulf F

Telling A

Robertson S M

Schartl M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/341415a0

Published

1989-10-05

Pages

415-21

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

X16891

External Links

PubMed source DOI: 10.1038/341415a0 View journal details

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Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus.

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