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PMID: 17124320 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.

Science (New York, N.Y.) ·Vol. 314 ·No. 5803 ·2006-11-24 ·Pages 1292-5

Brideau NJ, Flores HA, Wang J, Maheshwari S, Wang X, Barbash DA

Abstract

The Dobzhansky-Muller model proposes that hybrid incompatibilities are caused by the interaction between genes that have functionally diverged in the respective hybridizing species. Here, we show that Lethal hybrid rescue (Lhr) has functionally diverged in Drosophila simulans and interacts with Hybrid male rescue (Hmr), which has functionally diverged in D. melanogaster, to cause lethality in F1 hybrid males. LHR localizes to heterochromatic regions of the genome and has diverged extensively in sequence between these species in a manner consistent with positive selection. Rapidly evolving heterochromatic DNA sequences may be driving the evolution of this incompatibility gene.

MeSH Terms

Amino Acid Sequence Animals Chromosomal Proteins, Non-Histone/metabolism Chromosome Mapping Crosses, Genetic Drosophila/genetics,physiology Drosophila Proteins/chemistry,genetics,metabolism Drosophila melanogaster/genetics,physiology Evolution, Molecular Female Genes, Insect Genetic Speciation Hybridization, Genetic Male Molecular Sequence Data Selection, Genetic Transformation, Genetic Transgenes

Chemicals

Chromosomal Proteins, Non-Histone Drosophila Proteins Hmr protein, Drosophila Lhr protein, Drosophila heterochromatin protein 1, Drosophila

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Brideau Nicholas J

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

Flores Heather A

Wang Jun

Maheshwari Shamoni

Wang Xu

Barbash Daniel A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1133953

Published

2006-11-24

Pages

1292-5

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIGMS NIH HHS · R01 GM074737-01 · United States

Databases

GENBANK

BK005905, BK005906, BK005907, BK005908, BK005909, BK005910, BK005911, BK005912, BK005913, BK005914, EF044038, EF044039, EF044040, EF044041, EF044042, EF044043, EF044044, EF044045, EF044046, EF044047, EF044048, EF044049, EF044050, EF044051, EF044052, EF044053, EF044054, EF044055, EF044056, EF044057, EF044058, EF044059, EF044060, EF044061, EF044062, EF057388, EF057389

Corrections

CommentIn

PMID: 17124304

External Links

PubMed source DOI: 10.1126/science.1133953 View journal details

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Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.

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