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PMID: 19180105 Published · ppublish English Research Support, Non-U.S. Gov't Review

Mechanisms of drug combinations: interaction and network perspectives.

Nature reviews. Drug discovery ·Vol. 8 ·No. 2 ·2009-00-00 ·Pages 111-28

Jia J, Zhu F, Ma X, Cao Z, Cao ZW, Li Y, Li YX, Chen YZ

Abstract

Understanding the molecular mechanisms underlying synergistic, potentiative and antagonistic effects of drug combinations could facilitate the discovery of novel efficacious combinations and multi-targeted agents. In this article, we describe an extensive investigation of the published literature on drug combinations for which the combination effect has been evaluated by rigorous analysis methods and for which relevant molecular interaction profiles of the drugs involved are available. Analysis of the 117 drug combinations identified reveals general and specific modes of action, and highlights the potential value of molecular interaction profiles in the discovery of novel multicomponent therapies.

MeSH Terms
Drug Antagonism Drug Synergism Drug Therapy, Combination Humans
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Jia Jia
Bioinformatics and Drug Design Group, Department of Pharmacy, Department of Biological Science, Center for Computational Science and Engineering, National University of Singapore, Singapore 117543.
Zhu Feng
Ma Xiaohua
Cao Zhiwei
Cao Zhiwei W
Li Yixue
Li Yixue X
Chen Yu Zong
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Article Info
Journal
Nature reviews. Drug discovery
Abbr.
Nat Rev Drug Discov
ISSN
1474-1784
DOI
10.1038/nrd2683
Published
2009-00-00
Pages
111-28
Language
English
Region
England
NLM ID
101124171
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1038/nrd2683 View journal details
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