Why is cancer drug discovery so difficult?

Nature reviews. Drug discovery ·Vol. 6 ·No. 2 ·2007-00-00 ·Pages 115-20

Kamb A, Wee S, Lengauer C

Abstract

Thirty-five years after the 'war on cancer' was declared, the discovery of anticancer drugs remains a highly challenging endeavour. Here, we consider the factors responsible, such as tumour heterogeneity, and suggest strategies to improve the chances of short-term success in the development of novel anticancer drugs.

MeSH Terms

Animals Antineoplastic Agents/therapeutic use Benzamides Drug Design Humans Imatinib Mesylate Neoplasms/drug therapy,genetics Piperazines/therapeutic use Pyrimidines/therapeutic use Quantitative Trait Loci

Chemicals

Antineoplastic Agents Benzamides Piperazines Pyrimidines Imatinib Mesylate

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kamb Alexander

Amgen, 1120 Veterans Boulevard, South San Francisco, California 94010, USA.

Wee Susan

Lengauer Christoph

Article Info

Journal

Nature reviews. Drug discovery

Abbr.

Nat Rev Drug Discov

ISSN

1474-1776

DOI

10.1038/nrd2155

Published

2007-00-00

Epub

2006-00-08

Pages

115-20

Language

English

Region

England

NLM ID

101124171

Subset

External Links

PubMed source DOI: 10.1038/nrd2155 View journal details

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Why is cancer drug discovery so difficult?

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