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PMID: 19119265 Published · ppublish English Journal Article Review

Decanalization and the origin of complex disease.

Nature reviews. Genetics ·Vol. 10 ·No. 2 ·2009-02-00 ·Pages 134-40

Gibson G

Abstract

Complex genetic disease is caused by the interaction between genetic and environmental variables and is the predominant cause of mortality globally. Recognition that susceptibility arises through the combination of multiple genetic pathways that influence liability factors in a nonlinear manner suggests that a process of 'decanalization' contributes to the epidemic nature of common genetic diseases. The rapid evolution of the human genome combined with marked environmental and cultural perturbation in the past two generations might lead to the uncovering of cryptic genetic variation that is a major source of disease susceptibility.

MeSH Terms
Alleles Diabetes Mellitus, Type 2/genetics,metabolism Environment Genetic Diseases, Inborn/genetics Genetic Predisposition to Disease Humans Immune System Diseases/genetics Mental Disorders/genetics Models, Genetic
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gibson Greg
School of Integrative Biology, Goddard Building, St Lucia Campus, University of Queensland, Brisbane, Queensland 4072, Australia. ggibson.uq@gmail.com
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2502
Email
ggibson.uq@gmail.com
Published
2009-02-00
Epub
2009-00-02
Pages
134-40
Language
English
Region
England
NLM ID
100962779
Subset
IM
External Links
PubMed source DOI: 10.1038/nrg2502 View journal details
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