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PMID: 18604267 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.

PLoS genetics ·Vol. 4 ·No. 7 ·2008-07-04 ·Pages e1000118

Paré G, Chasman DI, Kellogg M, Zee RY, Rifai N, Badola S, Miletich JP, Ridker PM

Abstract

While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5x10(-8)), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1x10(-29)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.

MeSH Terms
ABO Blood-Group System/genetics,immunology,metabolism Female Genetic Linkage Genetic Variation Genome, Human Humans Intercellular Adhesion Molecule-1/blood,genetics Myocardial Infarction/immunology,metabolism Polymorphism, Single Nucleotide Solubility Women's Health
Chemicals
ABO Blood-Group System Intercellular Adhesion Molecule-1
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Paré Guillaume
Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. gpare@rics.bwh.harvard.edu
Chasman Daniel I
Kellogg Mark
Zee Robert Y L
Rifai Nader
Badola Sunita
Miletich Joseph P
Ridker Paul M
Conflict of Interest

The authors have declared that no competing interests exist.

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Article Info
Journal
PLoS genetics
Abbr.
PLoS Genet
ISSN
1553-7404
DOI
10.1371/journal.pgen.1000118
Email
gpare@rics.bwh.harvard.edu
Published
2008-07-04
Epub
2008-00-04
Pages
e1000118
Language
English
Region
United States
NLM ID
101239074
PMCID
PMC2432033
Subset
IM
External Links
PubMed source DOI: 10.1371/journal.pgen.1000118 PMC Full Text View journal details
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