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PMID: 17431167 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Evolutionary and biomedical insights from the rhesus macaque genome.

Science (New York, N.Y.) ·Vol. 316 ·No. 5822 ·2007-04-13 ·Pages 222-34

Rhesus Macaque Genome Sequencing and Analysis Consortium, Gibbs RA, Rogers J, Katze MG, Bumgarner R, Weinstock GM, Mardis ER, Remington KA, Strausberg RL, Venter JC, Wilson RK, Batzer MA, Bustamante CD, Eichler EE, Hahn MW, Hardison RC, Makova KD, Miller W, Milosavljevic A, Palermo RE, Siepel A, Sikela JM, Attaway T, Bell S, Bernard KE, Buhay CJ, Chandrabose MN, Dao M, Davis C, Delehaunty KD, Ding Y, Dinh HH, Dugan-Rocha S, Fulton LA, Gabisi RA, Garner TT, Godfrey J, Hawes AC, Hernandez J, Hines S, Holder M, Hume J, Jhangiani SN, Joshi V, Khan ZM, Kirkness EF, Cree A, Fowler RG, Lee S, Lewis LR, Li Z, Liu YS, Moore SM, Muzny D, Nazareth LV, Ngo DN, Okwuonu GO, Pai G, Parker D, Paul HA, Pfannkoch C, Pohl CS, Rogers YH, Ruiz SJ, Sabo A, Santibanez J, Schneider BW, Smith SM, Sodergren E, Svatek AF, Utterback TR, Vattathil S, Warren W, White CS, Chinwalla AT, Feng Y, Halpern AL, Hillier LW, Huang X, Minx P, Nelson JO, Pepin KH, Qin X, Sutton GG, Venter E, Walenz BP, Wallis JW, Worley KC, Yang SP, Jones SM, Marra MA, Rocchi M, Schein JE, Baertsch R, Clarke L, Csürös M, Glasscock J, Harris RA, Havlak P, Jackson AR, Jiang H, Liu Y, Messina DN, Shen Y, Song HX, Wylie T, Zhang L, Birney E, Han K, Konkel MK, Lee J, Smit AF, Ullmer B, Wang H, Xing J, Burhans R, Cheng Z, Karro JE, Ma J, Raney B, She X, Cox MJ, Demuth JP, Dumas LJ, Han SG, Hopkins J, Karimpour-Fard A, Kim YH, Pollack JR, Vinar T, Addo-Quaye C, Degenhardt J, Denby A, Hubisz MJ, Indap A, Kosiol C, Lahn BT, Lawson HA, Marklein A, Nielsen R, Vallender EJ, Clark AG, Ferguson B, Hernandez RD, Hirani K, Kehrer-Sawatzki H, Kolb J, Patil S, Pu LL, Ren Y, Smith DG, Wheeler DA, Schenck I, Ball EV, Chen R, Cooper DN, Giardine B, Hsu F, Kent WJ, Lesk A, Nelson DL, O'brien WE, Prüfer K, Stenson PD, Wallace JC, Ke H, Liu XM, Wang P, Xiang AP, Yang F, Barber GP, Haussler D, Karolchik D, Kern AD, Kuhn RM, Smith KE, Zwieg AS

Abstract

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

MeSH Terms
Animals Biomedical Research Evolution, Molecular Female Gene Duplication Gene Rearrangement Genetic Diseases, Inborn Genetic Variation Genome Humans Macaca mulatta/genetics Male Multigene Family Mutation Pan troglodytes/genetics Sequence Analysis, DNA Species Specificity
Authors & Affiliations
177 authors, click to expand affiliations / ORCID
Rhesus Macaque Genome Sequencing and Analysis Consortium
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. agibbs@bcm.edu
Gibbs Richard A
Rogers Jeffrey
Katze Michael G
Bumgarner Roger
Weinstock George M
Mardis Elaine R
Remington Karin A
Strausberg Robert L
Venter J Craig
Wilson Richard K
Batzer Mark A
Bustamante Carlos D
Eichler Evan E
Hahn Matthew W
Hardison Ross C
Makova Kateryna D
Miller Webb
Milosavljevic Aleksandar
Palermo Robert E
Siepel Adam
Sikela James M
Attaway Tony
Bell Stephanie
Bernard Kelly E
Buhay Christian J
Chandrabose Mimi N
Dao Marvin
Davis Clay
Delehaunty Kimberly D
Ding Yan
Dinh Huyen H
Dugan-Rocha Shannon
Fulton Lucinda A
Gabisi Ramatu Ayiesha
Garner Toni T
Godfrey Jennifer
Hawes Alicia C
Hernandez Judith
Hines Sandra
Holder Michael
Hume Jennifer
Jhangiani Shalini N
Joshi Vandita
Khan Ziad Mohid
Kirkness Ewen F
Cree Andrew
Fowler R Gerald
Lee Sandra
Lewis Lora R
Li Zhangwan
Liu Yih-Shin
Moore Stephanie M
Muzny Donna
Nazareth Lynne V
Ngo Dinh Ngoc
Okwuonu Geoffrey O
Pai Grace
Parker David
Paul Heidie A
Pfannkoch Cynthia
Pohl Craig S
Rogers Yu-Hui
Ruiz San Juana
Sabo Aniko
Santibanez Jireh
Schneider Brian W
Smith Scott M
Sodergren Erica
Svatek Amanda F
Utterback Teresa R
Vattathil Selina
Warren Wesley
White Courtney Sherell
Chinwalla Asif T
Feng Yucheng
Halpern Aaron L
Hillier Ladeana W
Huang Xiaoqiu
Minx Pat
Nelson Joanne O
Pepin Kymberlie H
Qin Xiang
Sutton Granger G
Venter Eli
Walenz Brian P
Wallis John W
Worley Kim C
Yang Shiaw-Pyng
Jones Steven M
Marra Marco A
Rocchi Mariano
Schein Jacqueline E
Baertsch Robert
Clarke Laura
Csürös Miklós
Glasscock Jarret
Harris R Alan
Havlak Paul
Jackson Andrew R
Jiang Huaiyang
Liu Yue
Messina David N
Shen Yufeng
Song Henry Xing-Zhi
Wylie Todd
Zhang Lan
Birney Ewan
Han Kyudong
Konkel Miriam K
Lee Jungnam
Smit Arian F A
Ullmer Brygg
Wang Hui
Xing Jinchuan
Burhans Richard
Cheng Ze
Karro John E
Ma Jian
Raney Brian
She Xinwei
Cox Michael J
Demuth Jeffery P
Dumas Laura J
Han Sang-Gook
Hopkins Janet
Karimpour-Fard Anis
Kim Young H
Pollack Jonathan R
Vinar Tomas
Addo-Quaye Charles
Degenhardt Jeremiah
Denby Alexandra
Hubisz Melissa J
Indap Amit
Kosiol Carolin
Lahn Bruce T
Lawson Heather A
Marklein Alison
Nielsen Rasmus
Vallender Eric J
Clark Andrew G
Ferguson Betsy
Hernandez Ryan D
Hirani Kashif
Kehrer-Sawatzki Hildegard
Kolb Jessica
Patil Shobha
Pu Ling-Ling
Ren Yanru
Smith David Glenn
Wheeler David A
Schenck Ian
Ball Edward V
Chen Rui
Cooper David N
Giardine Belinda
Hsu Fan
Kent W James
Lesk Arthur
Nelson David L
O'brien William E
Prüfer Kay
Stenson Peter D
Wallace James C
Ke Hui
Liu Xiao-Ming
Wang Peng
Xiang Andy Peng
Yang Fan
Barber Galt P
Haussler David
Karolchik Donna
Kern Andy D
Kuhn Robert M
Smith Kayla E
Zwieg Ann S
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2007-04-13
Pages
222-34
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
Wellcome Trust · 062023 · United Kingdom
NHGRI NIH HHS · R01 HG002939 · United States
NHGRI NIH HHS · U54 HG003068 · United States
NHGRI NIH HHS · U54 HG003079 · United States
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