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PMID: 19056129 Published · ppublish English Journal Article Review

The piglet as a model for B cell and immune system development.

Veterinary immunology and immunopathology ·Vol. 128 ·No. 1-3 ·2009-03-15 ·Pages 147-70

Butler JE, Lager KM, Splichal I, Francis D, Kacskovics I, Sinkora M, Wertz N, Sun J, Zhao Y, Brown WR, DeWald R, Dierks S, Muyldermans S, Lunney JK, McCray PB, Rogers CS, Welsh MJ, Navarro P, Klobasa F, Habe F, Ramsoondar J

Abstract

The ability to identify factors responsible for disease in all species depends on the ability to separate those factors which are environmental from those that are intrinsic. This is particularly important for studies on the development of the adaptive immune response of neonates. Studies on laboratory rodents or primates have been ambiguous because neither the effect of environmental nor maternal factors on the newborn can be controlled in mammals that: (i) transmit potential maternal immunoregulatory factors in utero and (ii) are altricial and cannot be reared after birth without their mothers. Employing the newborn piglet model can address each of these concerns. However, it comes at the price of having first to characterize the immune system of swine and its development. This review focuses on the porcine B cell system, especially on the methods used for its characterization in fetal studies and neonatal piglets. Understanding these procedures is important in the interpretation of the data obtained. Studies on neonatal piglets have (a) provided valuable information on the development of the adaptive immune system, (b) lead to important advances in evolutionary biology, (c) aided our understanding of passive immunity and (d) provided opportunities to use swine to address specific issues in veterinary and biomedical research and immunotherapy. This review summarizes the history of the development of the piglet as a model for antibody repertoire development, thus providing a framework to guide future investigators.

MeSH Terms
Animals Animals, Newborn/growth & development,immunology B-Lymphocytes/physiology Germ-Free Life Humans Immune System/growth & development Models, Animal Swine/embryology,growth & development,immunology
Authors & Affiliations
21 authors, click to expand affiliations / ORCID
Butler J E
Department of Microbiology, University of Iowa, Iowa City, IA, United States. john-butler@uiowa.edu
Lager K M
Splichal I
Francis D
Kacskovics I
Sinkora M
Wertz N
Sun J
Zhao Y
Brown W R
DeWald R
Dierks S
Muyldermans S
Lunney J K
McCray P B
Rogers C S
Welsh M J
Navarro P
Klobasa F
Habe F
Ramsoondar J
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Article Info
Journal
Veterinary immunology and immunopathology
Abbr.
Vet Immunol Immunopathol
ISSN
0165-2427
DOI
10.1016/j.vetimm.2008.10.321
Email
john-butler@uiowa.edu
Published
2009-03-15
Epub
2008-00-01
Pages
147-70
Language
English
Region
Netherlands
NLM ID
8002006
PMCID
PMC2828348
Subset
IM
Grants
NHLBI NIH HHS · P01 HL091842 · United States
NHLBI NIH HHS · P01 HL091842-010001 · United States
NHLBI NIH HHS · P01 HL051670 · United States
Howard Hughes Medical Institute · United States
NHLBI NIH HHS · P01 HL051670-14 · United States
External Links
PubMed source DOI: 10.1016/j.vetimm.2008.10.321 PMC Full Text View journal details
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