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PMID: 18758472 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Targeting of tetraspanin proteins--potential benefits and strategies.

Nature reviews. Drug discovery ·Vol. 7 ·No. 9 ·2008-09-00 ·Pages 747-58

Hemler ME

Abstract

The tetraspanin transmembrane proteins have emerged as key players in malignancy, the immune system, during fertilization and infectious disease processes. Tetraspanins engage in a wide range of specific molecular interactions, occurring through the formation of tetraspanin-enriched microdomains (TEMs). TEMs therefore serve as a starting point for understanding how tetraspanins affect cell signalling, adhesion, morphology, motility, fusion and virus infection. An abundance of recent evidence suggests that targeting tetraspanins, for example, by monoclonal antibodies, soluble large-loop proteins or RNAi technology, should be therapeutically beneficial.

MeSH Terms
Animals Antibodies, Monoclonal/pharmacology Drug Delivery Systems Humans Membrane Microdomains/metabolism Membrane Proteins/drug effects,metabolism Proteins/pharmacology RNA Interference Signal Transduction
Chemicals
Antibodies, Monoclonal Membrane Proteins Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hemler Martin E
Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachussetts 02115, USA. Martin_Hemler@dfci.harvard.edu
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Article Info
Journal
Nature reviews. Drug discovery
Abbr.
Nat Rev Drug Discov
ISSN
1474-1776
DOI
10.1038/nrd2659
Email
martin_hemler@dfci.harvard.edu
Published
2008-09-00
Pages
747-58
Language
English
Region
England
NLM ID
101124171
PMCID
PMC4737550
Subset
IM
Grants
NCI NIH HHS · R01 CA042368 · United States
NIGMS NIH HHS · R01 GM038903 · United States
NIGMS NIH HHS · GM38903 · United States
NCI NIH HHS · CA42368 · United States
External Links
PubMed source DOI: 10.1038/nrd2659 PMC Full Text View journal details
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