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PMID: 18570869 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.

Molecular cell ·Vol. 30 ·No. 6 ·2008-06-20 ·Pages 657-66

Smith DJ, Query CC, Konarska MM

Abstract

The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.

MeSH Terms
Adenosine Triphosphatases/genetics,metabolism Alternative Splicing Animals Base Sequence Humans Models, Genetic Mutation Nucleic Acid Conformation RNA/chemistry,genetics RNA Splicing/genetics RNA, Messenger/genetics Spliceosomes/genetics,metabolism
Chemicals
RNA, Messenger RNA Adenosine Triphosphatases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Smith Duncan J
The Rockefeller University, New York, NY 10065, USA.
Query Charles C
Konarska Maria M
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Article Info
Journal
Molecular cell
Abbr.
Mol Cell
ISSN
1097-4164
DOI
10.1016/j.molcel.2008.04.013
Published
2008-06-20
Pages
657-66
Language
English
Region
United States
NLM ID
9802571
PMCID
PMC2610350
Subset
IM
Grants
NIGMS NIH HHS · GM57829 · United States
NIGMS NIH HHS · R01 GM049044 · United States
NIGMS NIH HHS · GM49044 · United States
NIGMS NIH HHS · R01 GM057829 · United States
NIGMS NIH HHS · R01 GM057829-09 · United States
NIGMS NIH HHS · R01 GM049044-16 · United States
External Links
PubMed source DOI: 10.1016/j.molcel.2008.04.013 PMC Full Text View journal details
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