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PMID: 11343900 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Pre-mRNA splicing in the new millennium.

Current opinion in cell biology ·Vol. 13 ·No. 3 ·2001-06-00 ·Pages 302-9

Hastings ML, Krainer AR

Abstract

The past year has witnessed refinements in models of spliceosome assembly pathways and in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family function. The role of splicing in human genetic diseases has also received a lot of attention recently as exonic splicing enhancers become better understood.

MeSH Terms

Animals Biological Therapy/methods Genetic Variation/genetics Humans Models, Molecular Nuclear Proteins/genetics,metabolism RNA Precursors/genetics,metabolism RNA Splice Sites/genetics,physiology RNA Splicing/genetics,physiology RNA-Binding Proteins Serine-Arginine Splicing Factors Spliceosomes/genetics,metabolism

Chemicals

Nuclear Proteins RNA Precursors RNA Splice Sites RNA-Binding Proteins Serine-Arginine Splicing Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hastings M L

Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724-2208, USA.

Krainer A R

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(00)00212-x

Published

2001-06-00

Pages

302-9

Language

English

Region

England

NLM ID

8913428

Subset

Grants

NCI NIH HHS · CA13106 · United States

NIGMS NIH HHS · GM42699 · United States

External Links

PubMed source DOI: 10.1016/s0955-0674(00)00212-x View journal details

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Pre-mRNA splicing in the new millennium.

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