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PMID: 18568039 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Mediators of reprogramming: transcription factors and transitions through mitosis.

Nature reviews. Molecular cell biology ·Vol. 9 ·No. 7 ·2008-07-00 ·Pages 505-16

Egli D, Birkhoff G, Eggan K

Abstract

It is thought that most cell types of the human body share the same genetic information as that contained in the zygote from which they originate. Consistent with this view, animal cloning studies demonstrated that the intact genome of a differentiated cell can be reprogrammed to support the development of an entire organism and allow the production of pluripotent stem cells. Recent progress in reprogramming research now points to an important role for transcription factors in the establishment and the maintenance of cellular phenotypes, and to cell division as a mediator of transitions between different states of gene expression.

MeSH Terms
Animals Cell Nucleus/metabolism Cloning, Organism/methods Epigenesis, Genetic Gene Expression Regulation Humans Mitosis/physiology Nuclear Transfer Techniques Pluripotent Stem Cells/cytology,physiology Transcription Factors/metabolism Transcription, Genetic
Chemicals
Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Egli Dieter
The Stowers Medical Institute, Harvard Stem Cell Institute and the Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
Birkhoff Garrett
Eggan Kevin
References (163)
163 references, click to expand
  1. Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells.
    Curr Biol. 2002 Jun 25;12(12):1016-20 PMID: 12123576
  2. Chromatin modifications and their function.
    Cell. 2007 Feb 23;128(4):693-705 PMID: 17320507
  3. Human therapeutic cloning.
    Nat Med. 1999 Sep;5(9):975-7 PMID: 10470061
  4. Generation of germline-competent induced pluripotent stem cells.
    Nature. 2007 Jul 19;448(7151):313-7 PMID: 17554338
  5. Germinal vesicle material is essential for nucleus remodeling after nuclear transfer.
    Biol Reprod. 2002 Sep;67(3):928-34 PMID: 12193404
  6. Chromatin motion is constrained by association with nuclear compartments in human cells.
    Curr Biol. 2002 Mar 19;12(6):439-45 PMID: 11909528
  7. Nuclear transplantation in sheep embryos.
    Nature. 1986 Mar 6-12;320(6057):63-5 PMID: 3951549
  8. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells.
    Science. 2005 Aug 26;309(5739):1369-73 PMID: 16123299
  9. TBP dynamics in living human cells: constitutive association of TBP with mitotic chromosomes.
    Mol Biol Cell. 2002 Jan;13(1):276-84 PMID: 11809839
  10. The Drosophila trithorax protein is a coactivator required to prevent re-establishment of polycomb silencing.
    Development. 2002 May;129(10):2483-93 PMID: 11973279
  11. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing.
    Nat Cell Biol. 2008 Apr;10(4):452-9 PMID: 18311132
  12. A distinct G1 step required to specify the Chinese hamster DHFR replication origin.
    Science. 1996 Mar 1;271(5253):1270-2 PMID: 8638106
  13. ACTIVE AND INACTIVE REGIONS OF NUCLEAR CHROMATIN AS REVEALED BY ELECTRON MICROSCOPE AUTORADIOGRAPHY.
    Proc Natl Acad Sci U S A. 1964 Jul;52:93-100 PMID: 14192663
  14. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.
    Cell. 2008 Feb 22;132(4):567-82 PMID: 18295576
  15. Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling.
    Hum Reprod. 2007 Aug;22(8):2232-42 PMID: 17562675
  16. The future of cloning.
    Nature. 1999 Dec 16;402(6763):743-6 PMID: 10617195
  17. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
    Nature. 2001 Mar 1;410(6824):116-20 PMID: 11242053
  18. Translating the histone code.
    Science. 2001 Aug 10;293(5532):1074-80 PMID: 11498575
  19. Dynamic reprogramming of DNA methylation in the early mouse embryo.
    Dev Biol. 2002 Jan 1;241(1):172-82 PMID: 11784103
  20. Association of human TFIID-promoter complexes with silenced mitotic chromatin in vivo.
    Nat Cell Biol. 2002 Jan;4(1):79-82 PMID: 11744923
  21. Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus.
    Stem Cells. 2006 Sep;24(9):2007-13 PMID: 16709876
  22. Reprogramming of human somatic cells to pluripotency with defined factors.
    Nature. 2008 Jan 10;451(7175):141-6 PMID: 18157115
  23. A nucleosome-dependent static loop potentiates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro.
    EMBO J. 1993 Feb;12(2):423-33 PMID: 8440235
  24. Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.
    Genes Dev. 1998 Sep 15;12(18):2842-51 PMID: 9744861
  25. Active repression of methylated genes by the chromosomal protein MBD1.
    Mol Cell Biol. 2000 Feb;20(4):1394-406 PMID: 10648624
  26. Nucleic acid synthesis in relation to the cell division cycle.
    Ann N Y Acad Sci. 1960 Oct 7;90:409-21 PMID: 13775619
  27. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
    Cell. 2006 Aug 25;126(4):663-76 PMID: 16904174
  28. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.
    Cell. 2006 May 5;125(3):483-95 PMID: 16603237
  29. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.
    Nature. 2007 Sep 27;449(7161):473-7 PMID: 17851532
  30. Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks.
    Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11112-7 PMID: 16840560
  31. Nuclear transplantation in mouse embryos: assessment of recipient cell stage.
    Biol Reprod. 1986 May;34(4):733-9 PMID: 3708053
  32. Gene bookmarking: keeping the pages open.
    Trends Biochem Sci. 2005 Nov;30(11):605-10 PMID: 16188444
  33. Mice cloned from olfactory sensory neurons.
    Nature. 2004 Mar 4;428(6978):44-9 PMID: 14990966
  34. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells.
    Science. 2000 Apr 28;288(5466):665-9 PMID: 10784448
  35. Asymmetric cell division during animal development.
    Nat Rev Mol Cell Biol. 2001 Jan;2(1):11-20 PMID: 11413461
  36. Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes.
    Curr Opin Genet Dev. 2002 Apr;12(2):210-8 PMID: 11893495
  37. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin.
    Cell. 1997 Feb 21;88(4):471-81 PMID: 9038338
  38. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.
    Cell Stem Cell. 2007 Jun 7;1(1):55-70 PMID: 18371336
  39. Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation.
    Nature. 2005 Dec 22;438(7071):1116-22 PMID: 16222246
  40. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
    Nature. 2007 Jul 19;448(7151):318-24 PMID: 17554336
  41. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter.
    Cell. 2000 Nov 10;103(4):667-78 PMID: 11106736
  42. Development of single blastomeres from four- and eight-cell mouse embryos fused into the enucleated half of a two-cell embryo.
    Gamete Res. 1989 Apr;22(4):427-34 PMID: 2722123
  43. Mechanisms of transcriptional memory.
    Nat Rev Mol Cell Biol. 2001 Jun;2(6):409-21 PMID: 11389465
  44. Reversing histone methylation.
    Nature. 2005 Aug 25;436(7054):1103-6 PMID: 16121170
  45. Stability and flexibility of epigenetic gene regulation in mammalian development.
    Nature. 2007 May 24;447(7143):425-32 PMID: 17522676
  46. Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals.
    Nature. 1998 Jun 11;393(6685):599-601 PMID: 9634239
  47. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins.
    Annu Rev Genet. 2004;38:413-43 PMID: 15568982
  48. Nuclear reprogramming: the zygotic transcription program is established through an "erase-and-rebuild" strategy.
    Cell Res. 2007 Feb;17(2):117-34 PMID: 17287829
  49. Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3.
    EMBO Rep. 2004 May;5(5):490-6 PMID: 15105826
  50. Bookmarking genes for activation in condensed mitotic chromosomes.
    Bioessays. 1998 Apr;20(4):275-9 PMID: 9619097
  51. Nuclear cloning and epigenetic reprogramming of the genome.
    Science. 2001 Aug 10;293(5532):1093-8 PMID: 11498580
  52. Disappearance of nucleosome positioning in mitotic chromatin in vivo.
    J Biol Chem. 2005 Apr 15;280(15):14530-5 PMID: 15705567
  53. Cloned rabbits produced by nuclear transfer from adult somatic cells.
    Nat Biotechnol. 2002 Apr;20(4):366-9 PMID: 11923842
  54. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse.
    Cell Stem Cell. 2008 Mar 6;2(3):230-40 PMID: 18371448
  55. Interaction of proteins with promoter elements of the human U2 snRNA genes in vivo.
    Gene. 2003 Oct 2;315:103-12 PMID: 14557070
  56. Monoclonal mice generated by nuclear transfer from mature B and T donor cells.
    Nature. 2002 Feb 28;415(6875):1035-8 PMID: 11875572
  57. Assessment of cytoplasmic effects on the development of mouse embryonic nuclei transferred to enucleated zygotes.
    Theriogenology. 1993 Feb;39(2):451-61 PMID: 16727225
  58. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation.
    Proc Natl Acad Sci U S A. 2001 May 22;98(11):6209-14 PMID: 11331774
  59. Synthesis of RNA and protein during mitosis in mammalian tissue culture cells.
    Exp Cell Res. 1962 Mar;26:260-8 PMID: 14488623
  60. ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable.
    Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):933-8 PMID: 16418286
  61. Heterochromatin protein 1 distribution during development and during the cell cycle in Drosophila embryos.
    J Cell Sci. 1995 Apr;108 ( Pt 4):1407-18 PMID: 7615662
  62. Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase.
    J Cell Sci. 2003 Aug 15;116(Pt 16):3327-38 PMID: 12840071
  63. Transient cyclical methylation of promoter DNA.
    Nature. 2008 Mar 6;452(7183):112-5 PMID: 18322535
  64. Mutations in the fission yeast silencing factors clr4+ and rik1+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function.
    J Cell Sci. 1996 Nov;109 ( Pt 11):2637-48 PMID: 8937982
  65. Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI.
    Science. 2000 Sep 29;289(5488):2360-2 PMID: 11009424
  66. Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.
    J Cell Biol. 2004 Dec 20;167(6):1025-35 PMID: 15596546
  67. Transcriptional repression mediated by repositioning of genes to the nuclear lamina.
    Nature. 2008 Mar 13;452(7184):243-7 PMID: 18272965
  68. Clonal inheritance of the pattern of DNA methylation in mouse cells.
    Proc Natl Acad Sci U S A. 1982 Jan;79(1):61-5 PMID: 6459581
  69. MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.
    J Biol Chem. 2005 Feb 18;280(7):5178-87 PMID: 15563468
  70. Preimplantation development of rabbit embryos after transfer of embryonic nuclei into different cytoplasmic environment.
    Mol Reprod Dev. 1991 Apr;28(4):361-72 PMID: 2064779
  71. Epigenetic reprogramming in mammals.
    Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R47-58 PMID: 15809273
  72. Dissociation of mammalian Polycomb-group proteins, Ring1B and Rae28/Ph1, from the chromatin correlates with configuration changes of the chromatin in mitotic and meiotic prophase.
    Histochem Cell Biol. 2003 Aug;120(2):111-9 PMID: 12883906
  73. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals.
    EMBO J. 2000 Jun 1;19(11):2728-38 PMID: 10835370
  74. Stabilization of chromatin structure by PRC1, a Polycomb complex.
    Cell. 1999 Jul 9;98(1):37-46 PMID: 10412979
  75. Chromosome order in HeLa cells changes during mitosis and early G1, but is stably maintained during subsequent interphase stages.
    J Cell Biol. 2003 Mar 3;160(5):685-97 PMID: 12604593
  76. Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos.
    Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13734-8 PMID: 11717434
  77. A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition.
    Genes Dev. 2008 Apr 1;22(7):860-5 PMID: 18381889
  78. Polycomb silencing mechanisms and the management of genomic programmes.
    Nat Rev Genet. 2007 Jan;8(1):9-22 PMID: 17173055
  79. Nuclear transplantation in the mouse embryo by microsurgery and cell fusion.
    Science. 1983 Jun 17;220(4603):1300-2 PMID: 6857250
  80. The epigenomics of cancer.
    Cell. 2007 Feb 23;128(4):683-92 PMID: 17320506
  81. An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA.
    EMBO J. 1998 Mar 2;17(5):1446-53 PMID: 9482741
  82. The GAGA factor is required in the early Drosophila embryo not only for transcriptional regulation but also for nuclear division.
    Development. 1996 Apr;122(4):1113-24 PMID: 8620838
  83. Developmental reprogramming after chromosome transfer into mitotic mouse zygotes.
    Nature. 2007 Jun 7;447(7145):679-85 PMID: 17554301
  84. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells.
    Curr Biol. 2001 Oct 2;11(19):1553-8 PMID: 11591326
  85. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
    Nature. 2001 Mar 1;410(6824):120-4 PMID: 11242054
  86. Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer.
    Biochem Biophys Res Commun. 2006 Feb 3;340(1):183-9 PMID: 16356478
  87. Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei.
    Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12889-94 PMID: 12235366
  88. Gene activation in somatic nuclei after injection into amphibian oocytes.
    Proc Natl Acad Sci U S A. 1977 Jun;74(6):2470-4 PMID: 267940
  89. Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres.
    J Cell Sci. 2000 Mar;113 ( Pt 5):817-29 PMID: 10671371
  90. Plasticity of the differentiated state.
    Science. 1985 Nov 15;230(4727):758-66 PMID: 2414846
  91. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.
    Cell. 2000 Aug 4;102(3):279-91 PMID: 10975519
  92. Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' Eggs.
    Proc Natl Acad Sci U S A. 1952 May;38(5):455-63 PMID: 16589125
  93. Condensation of chromatin into chromosomes preserves an open configuration but alters the DNase I hypersensitive cleavage sites of the transcribed gene.
    Nucleic Acids Res. 1982 Aug 11;10(15):4565-79 PMID: 6215624
  94. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.
    Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8963-8 PMID: 15184648
  95. Generation of cloned mice by direct nuclear transfer from natural killer T cells.
    Curr Biol. 2005 Jun 21;15(12):1114-8 PMID: 15964276
  96. Viable offspring derived from fetal and adult mammalian cells.
    Nature. 1997 Feb 27;385(6619):810-3 PMID: 9039911
  97. Nucleosome destabilization in the epigenetic regulation of gene expression.
    Nat Rev Genet. 2008 Jan;9(1):15-26 PMID: 18059368
  98. Polycomb, epigenomes, and control of cell identity.
    Cell. 2003 Mar 7;112(5):599-606 PMID: 12628181
  99. Differential transcriptional activity associated with chromatin configuration in fully grown mouse germinal vesicle oocytes.
    Biol Reprod. 1999 Mar;60(3):580-7 PMID: 10026102
  100. Oct4 distribution and level in mouse clones: consequences for pluripotency.
    Genes Dev. 2002 May 15;16(10):1209-19 PMID: 12023300
  101. Aurora-B/AIM-1 regulates the dynamic behavior of HP1alpha at the G2-M transition.
    Mol Biol Cell. 2006 Jul;17(7):3232-41 PMID: 16687578
  102. Lineages, quantal cell cycles, and the generation of cell diversity.
    Q Rev Biophys. 1975 Nov;8(4):523-57 PMID: 769044
  103. Mitotic repression of the transcriptional machinery.
    Trends Biochem Sci. 1997 Jun;22(6):197-202 PMID: 9204705
  104. Cyclical DNA methylation of a transcriptionally active promoter.
    Nature. 2008 Mar 6;452(7183):45-50 PMID: 18322525
  105. Nuclear and chromosomal behavior in amphibian nuclear transplants.
    Int Rev Cytol Suppl. 1979;(9):129-60 PMID: 385534
  106. Mechanisms of asymmetric cell division: flies and worms pave the way.
    Nat Rev Mol Cell Biol. 2008 May;9(5):355-66 PMID: 18431399
  107. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.
    Nat Cell Biol. 2007 Mar;9(3):347-53 PMID: 17277772
  108. Pluripotential reprogramming of the somatic genome in hybrid cells occurs with the first cell cycle.
    Stem Cells. 2008 Feb;26(2):445-54 PMID: 18065396
  109. Expression of muscle genes in heterokaryons depends on gene dosage.
    J Cell Biol. 1986 Jan;102(1):124-30 PMID: 3941151
  110. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.
    Cell Stem Cell. 2008 Feb 7;2(2):151-9 PMID: 18371436
  111. Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin.
    Nature. 2005 Dec 22;438(7071):1176-80 PMID: 16222244
  112. Regulation of chromatin structure by site-specific histone H3 methyltransferases.
    Nature. 2000 Aug 10;406(6796):593-9 PMID: 10949293
  113. Full-term development of mouse blastomere nuclei transplanted into enucleated two-cell embryos.
    J Exp Zool. 1987 May;242(2):147-51 PMID: 3612046
  114. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.
    Nat Genet. 2003 Mar;33 Suppl:245-54 PMID: 12610534
  115. Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells.
    Nat Cell Biol. 2007 Jun;9(6):625-35 PMID: 17515932
  116. The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs.
    J Embryol Exp Morphol. 1975 Aug;34(1):93-112 PMID: 1102625
  117. Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer.
    Biol Reprod. 2006 Jun;74(6):1083-9 PMID: 16481594
  118. Changes in chromosomal localization of heterochromatin-binding proteins during the cell cycle in Drosophila.
    J Cell Biol. 1998 Mar 23;140(6):1297-306 PMID: 9508764
  119. Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions.
    Nat Rev Genet. 2007 Feb;8(2):104-15 PMID: 17230197
  120. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development.
    Science. 2002 Apr 5;296(5565):158-62 PMID: 11935030
  121. Metaphase chromosome analysis by ligation-mediated PCR: heritable chromatin structure and a comparison of active and inactive X chromosomes.
    Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2379-83 PMID: 7892275
  122. Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator.
    Nat Cell Biol. 2001 Feb;3(2):134-9 PMID: 11175745
  123. The mammalian epigenome.
    Cell. 2007 Feb 23;128(4):669-81 PMID: 17320505
  124. Inability of mouse blastomere nuclei transferred to enucleated zygotes to support development in vitro.
    Science. 1984 Dec 14;226(4680):1317-9 PMID: 6542249
  125. The language of covalent histone modifications.
    Nature. 2000 Jan 6;403(6765):41-5 PMID: 10638745
  126. The human polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain.
    J Cell Biol. 1998 Aug 24;142(4):887-98 PMID: 9722603
  127. Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei.
    Nature. 1958 Jul 5;182(4627):64-5 PMID: 13566187
  128. Mitotic remodeling of the replicon and chromosome structure.
    Cell. 2005 Dec 2;123(5):787-801 PMID: 16325575
  129. Cohesin mediates transcriptional insulation by CCCTC-binding factor.
    Nature. 2008 Feb 14;451(7180):796-801 PMID: 18235444
  130. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.
    Cell. 2008 Apr 18;133(2):250-64 PMID: 18423197
  131. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells.
    Nat Genet. 2000 Apr;24(4):372-6 PMID: 10742100
  132. Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
    Cell. 2007 Nov 30;131(5):861-72 PMID: 18035408
  133. Native and recombinant polycomb group complexes establish a selective block to template accessibility to repress transcription in vitro.
    Mol Cell Biol. 2002 Nov;22(22):7919-28 PMID: 12391159
  134. Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains.
    Genes Dev. 2003 Aug 1;17(15):1870-81 PMID: 12897054
  135. Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.
    Genes Dev. 1995 Jan 15;9(2):218-33 PMID: 7851795
  136. The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin.
    Curr Biol. 1996 Nov 1;6(11):1416-25 PMID: 8939603
  137. Changing cell fate by nuclear reprogramming.
    Cell Cycle. 2005 Apr;4(4):513-5 PMID: 15753660
  138. Drosophila Polycomb-group regulated chromatin inhibits the accessibility of a trans-activator to its target DNA.
    EMBO J. 1995 Nov 15;14(22):5660-71 PMID: 8521823
  139. Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products.
    Development. 1992 Feb;114(2):493-505 PMID: 1350533
  140. The inheritance of epigenetic defects.
    Science. 1987 Oct 9;238(4824):163-70 PMID: 3310230
  141. Ribonucleic acid and protein synthesis in mitotic HeLa cells.
    J Cell Biol. 1965 Dec;27(3):565-74 PMID: 4287276
  142. The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.
    EMBO J. 1996 Jul 1;15(13):3394-402 PMID: 8670841
  143. Phenotypic plasticity and the epigenetics of human disease.
    Nature. 2007 May 24;447(7143):433-40 PMID: 17522677
  144. Transcriptional reprogramming of somatic cell nuclei during preimplantation development of cloned bovine embryos.
    Dev Biol. 2007 May 15;305(2):637-49 PMID: 17359962
  145. The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins.
    EMBO Rep. 2004 Apr;5(4):373-7 PMID: 15031712
  146. Active RNA polymerases are localized within discrete transcription "factories' in human nuclei.
    J Cell Sci. 1996 Jun;109 ( Pt 6):1427-36 PMID: 8799830
  147. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.
    Nat Genet. 2002 Jan;30(1):77-80 PMID: 11740497
  148. Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization.
    Genes Dev. 1996 Oct 1;10(19):2389-400 PMID: 8843192
  149. Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins.
    Mol Cell. 1999 Oct;4(4):529-40 PMID: 10549285
  150. The distribution of polycomb-group proteins during cell division and development in Drosophila embryos: impact on models for silencing.
    J Cell Biol. 1998 Apr 20;141(2):469-81 PMID: 9548724
  151. The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly.
    Mol Cell. 2002 Jun;9(6):1191-200 PMID: 12086617
  152. Displacement of sequence-specific transcription factors from mitotic chromatin.
    Cell. 1995 Oct 6;83(1):29-38 PMID: 7553870
  153. Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells.
    Chromosoma. 1999 Aug;108(4):220-34 PMID: 10460410
  154. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.
    Proc Natl Acad Sci U S A. 1989 Jul;86(14):5434-8 PMID: 2748593
  155. The Drosophila GAGA transcription factor is associated with specific regions of heterochromatin throughout the cell cycle.
    EMBO J. 1994 Dec 15;13(24):5977-83 PMID: 7813435
  156. Nuclear transfer into mouse zygotes.
    Nat Genet. 2000 Feb;24(2):108-9 PMID: 10655051
  157. Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status.
    J Cell Sci. 1999 Dec;112 ( Pt 24):4627-39 PMID: 10574711
  158. Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes.
    PLoS Biol. 2005 May;3(5):e157 PMID: 15839726
  159. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei.
    Nature. 1998 Jul 23;394(6691):369-74 PMID: 9690471
  160. DNA methylation patterns and epigenetic memory.
    Genes Dev. 2002 Jan 1;16(1):6-21 PMID: 11782440
  161. Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos.
    Curr Biol. 2003 Jul 1;13(13):1116-21 PMID: 12842010
  162. Induced pluripotent stem cell lines derived from human somatic cells.
    Science. 2007 Dec 21;318(5858):1917-20 PMID: 18029452
  163. Molecular behavior in living mitotic cells of human centromere heterochromatin protein HPLalpha ectopically expressed as a fusion to red fluorescent protein.
    Cell Struct Funct. 2001 Dec;26(6):705-18 PMID: 11942629
Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2439
Published
2008-07-00
Pages
505-16
Language
English
Region
England
NLM ID
100962782
PMCID
PMC7250051
Subset
IM
Grants
NICHD NIH HHS · R01 HD046732 · United States
External Links
PubMed source DOI: 10.1038/nrm2439 PMC Full Text View journal details
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