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PMID: 18474937 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Histone modifications and nuclear architecture: a review.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society ·Vol. 56 ·No. 8 ·2008-08-00 ·Pages 711-21

Bártová E, Krejcí J, Harnicarová A, Galiová G, Kozubek S

Abstract

Epigenetic modifications, such as acetylation, phosphorylation, methylation, ubiquitination, and ADP ribosylation, of the highly conserved core histones, H2A, H2B, H3, and H4, influence the genetic potential of DNA. The enormous regulatory potential of histone modification is illustrated in the vast array of epigenetic markers found throughout the genome. More than the other types of histone modification, acetylation and methylation of specific lysine residues on N-terminal histone tails are fundamental for the formation of chromatin domains, such as euchromatin, and facultative and constitutive heterochromatin. In addition, the modification of histones can cause a region of chromatin to undergo nuclear compartmentalization and, as such, specific epigenetic markers are non-randomly distributed within interphase nuclei. In this review, we summarize the principles behind epigenetic compartmentalization and the functional consequences of chromatin arrangement within interphase nuclei.

MeSH Terms
Acetylation Animals Cell Nucleus/metabolism,ultrastructure Chromatin/ultrastructure Chromobox Protein Homolog 5 Chromosomal Proteins, Non-Histone/physiology Chromosomes, Human, X/metabolism Epigenesis, Genetic Gene Expression Histone Deacetylase Inhibitors Histones/genetics,metabolism Humans Interphase Methylation
Chemicals
Chromatin Chromosomal Proteins, Non-Histone Histone Deacetylase Inhibitors Histones Chromobox Protein Homolog 5
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bártová Eva
Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic. bartova@ibp.cz
Krejcí Jana
Harnicarová Andrea
Galiová Gabriela
Kozubek Stanislav
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Article Info
Journal
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Abbr.
J Histochem Cytochem
ISSN
0022-1554
DOI
10.1369/jhc.2008.951251
Email
bartova@ibp.cz
Published
2008-08-00
Epub
2008-00-12
Pages
711-21
Language
English
Region
United States
NLM ID
9815334
PMCID
PMC2443610
Subset
IM
External Links
PubMed source DOI: 10.1369/jhc.2008.951251 PMC Full Text View journal details
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