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PMID: 15940285 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?

EMBO reports ·Vol. 6 ·No. 6 ·2005-06-00 ·Pages 520-4

Taddei A, Roche D, Bickmore WA, Almouzni G

Abstract

Histone acetylation regulates many chromosome functions, such as gene expression and chromosome segregation. Histone deacetylase inhibitors (HDACIs) induce growth arrest, differentiation and apoptosis of cancer cells ex vivo, as well as in vivo in tumour-bearing animal models, and are now undergoing clinical trials as anti-tumour agents. However, little attention has been paid to how HDACIs function in these biological settings and why different cells respond in different ways. Here, we discuss the consequences of inhibiting histone deacetylases in cycling versus non-cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome.

MeSH Terms
Cell Cycle/drug effects Heterochromatin/drug effects,metabolism Histone Deacetylase Inhibitors Histones/drug effects,metabolism Hydroxamic Acids/pharmacology,therapeutic use Neoplasms/drug therapy
Chemicals
Heterochromatin Histone Deacetylase Inhibitors Histones Hydroxamic Acids trichostatin A
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Taddei Angela
Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d'Ulm, 75248 Paris cedex 05, France.
Roche Danièle
Bickmore Wendy A
Almouzni Geneviève
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1038/sj.embor.7400441
Published
2005-06-00
Pages
520-4
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1369099
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.embor.7400441 PMC Full Text View journal details
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