Home LiteratureArticle Details
PMID: 1846445 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 2 ·1991-01-15 ·Pages 557-60

Delgado R, Hidalgo P, Diaz F, Latorre R, Labarca P

Abstract

Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.

MeSH Terms
8-Bromo Cyclic Adenosine Monophosphate/pharmacology Animals Cyclic AMP/pharmacology,physiology Cyclic GMP/pharmacology Drosophila/genetics,physiology Larva Membrane Potentials/drug effects Muscles/physiology Mutation Potassium Channels/drug effects,genetics,physiology
Chemicals
Potassium Channels 8-Bromo Cyclic Adenosine Monophosphate Cyclic AMP Cyclic GMP
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Delgado R
Centro de Estudios Cientificos de Santiago, Chile.
Hidalgo P
Diaz F
Latorre R
Labarca P
References (24)
24 references, click to expand
  1. Single-channel and genetic analyses reveal two distinct A-type potassium channels in Drosophila.
    Science. 1987 May 29;236(4805):1094-8 PMID: 2437657
  2. Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment.
    Nature. 1985 Jan 24-30;313(6000):310-3 PMID: 2578616
  3. Genetics of ion channels.
    Physiol Rev. 1986 Apr;66(2):301-29 PMID: 2421364
  4. Genetics and molecular biology of ionic channels in Drosophila.
    Annu Rev Neurosci. 1986;9:255-76 PMID: 2423005
  5. Phosphorylation of ion channels.
    J Membr Biol. 1985;87(3):177-90 PMID: 2416932
  6. Varieties of calcium-activated potassium channels.
    Annu Rev Physiol. 1989;51:385-99 PMID: 2653189
  7. Voltage-gated potassium channels in larval CNS neurons of Drosophila.
    J Neurosci. 1988 Jul;8(7):2556-70 PMID: 3249242
  8. Single-channel analysis of four distinct classes of potassium channels in Drosophila muscle.
    J Neurosci. 1988 Dec;8(12):4765-79 PMID: 3199204
  9. Isolation of the Drosophila melanogaster dunce chromosomal region and recombinational mapping of dunce sequences with restriction site polymorphisms as genetic markers.
    Mol Cell Biol. 1984 Feb;4(2):358-67 PMID: 6321960
  10. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.
    Pflugers Arch. 1981 Aug;391(2):85-100 PMID: 6270629
  11. Genetic modification of potassium channels in Drosophila Shaker mutants.
    Nature. 1981 Sep 17-23;293(5829):228-30 PMID: 6268986
  12. Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system.
    J Cell Biol. 1981 Jul;90(1):101-7 PMID: 6265472
  13. The automated analysis of data from single ionic channels.
    Pflugers Arch. 1982 Dec;395(4):331-40 PMID: 6296760
  14. Genetic alteration of nerve membrane excitability in temperature-sensitive paralytic mutants of Drosophila melanogaster.
    Nature. 1980 Aug 21;286(5775):814-6 PMID: 6250083
  15. Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster.
    Nature. 1981 Jan 1;289(5793):79-81 PMID: 6256649
  16. The effect of sodium ions on the electrical activity of giant axon of the squid.
    J Physiol. 1949 Mar 1;108(1):37-77 PMID: 18128147
  17. Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase.
    Proc Natl Acad Sci U S A. 1986 Dec;83(24):9313-7 PMID: 3025834
  18. A cyclic nucleotide-gated conductance in olfactory receptor cilia.
    Nature. 1987 Jan 29-Feb 4;325(6103):442-4 PMID: 3027574
  19. Neurogenetic dissection of learning and short-term memory in Drosophila.
    Annu Rev Neurosci. 1988;11:537-63 PMID: 3129981
  20. L-glutamate activates excitatory and inhibitory channels in Drosophila larval muscle.
    FEBS Lett. 1989 Jan 30;243(2):337-42 PMID: 2465185
  21. Cyclic GMP-activated conductance of retinal photoreceptor cells.
    Annu Rev Neurosci. 1989;12:289-327 PMID: 2467600
  22. Ion channels in Drosophila.
    Annu Rev Physiol. 1988;50:379-94 PMID: 2454072
  23. Activation by divalent cations of a Ca2+-activated K+ channel from skeletal muscle membrane.
    J Gen Physiol. 1988 Jul;92(1):67-86 PMID: 3171535
  24. A Drosophila mutation that eliminates a calcium-dependent potassium current.
    Proc Natl Acad Sci U S A. 1986 Nov;83(21):8415-9 PMID: 2430288
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.2.557
Published
1991-01-15
Pages
557-60
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC50850
Subset
IM
Grants
NIGMS NIH HHS · GM-35981 · United States
External Links
PubMed source DOI: 10.1073/pnas.88.2.557 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2