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PMID: 18456486 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

BAFF and the plasticity of peripheral B cell tolerance.

Current opinion in immunology ·Vol. 20 ·No. 2 ·2008-04-00 ·Pages 158-61

Stadanlick JE, Cancro MP

Abstract

BAFF and its receptors play a crucial role in peripheral B cell selection and survival, by dictating the set point for mature primary B cell numbers and adjusting thresholds for specificity-based selection during transitional differentiation. The notion that selective stringency can be varied on the basis of homeostatic demands reveals a previously unappreciated degree of plasticity in B cell tolerance, and suggests a paradigm that unites peripheral negative and positive selection with the maintenance of mature B cell numbers. Moreover, it implies a developmentally regulated coupling of BCR and BAFF receptors at the transitional stages and beyond.

MeSH Terms
Animals B-Cell Activating Factor/metabolism B-Cell Activation Factor Receptor/metabolism B-Lymphocytes/immunology Humans Immune Tolerance Mice Receptors, Antigen, B-Cell/metabolism Signal Transduction
Chemicals
B-Cell Activating Factor B-Cell Activation Factor Receptor Receptors, Antigen, B-Cell
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stadanlick Jason E
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, United States.
Cancro Michael P
References (36)
36 references, click to expand
  1. Space, selection, and surveillance: setting boundaries with BLyS.
    J Immunol. 2006 Jun 1;176(11):6405-10 PMID: 16709796
  2. Evidence for the clonal abortion theory of B-lymphocyte tolerance.
    J Exp Med. 1975 Apr 1;141(4):904-17 PMID: 47889
  3. NF-kappaB guides the survival and differentiation of developing lymphocytes.
    Cell Death Differ. 2006 May;13(5):697-701 PMID: 16528380
  4. Predominant autoantibody production by early human B cell precursors.
    Science. 2003 Sep 5;301(5638):1374-7 PMID: 12920303
  5. Reduced life span of anergic self-reactive B cells in a double-transgenic model.
    J Exp Med. 1994 Jan 1;179(1):125-34 PMID: 8270860
  6. Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse.
    J Immunol. 1996 Jul 15;157(2):598-606 PMID: 8752907
  7. Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency.
    Curr Biol. 2001 Oct 2;11(19):1547-52 PMID: 11591325
  8. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.
    Immunity. 2004 Jun;20(6):785-98 PMID: 15189742
  9. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.
    Nature. 1994 Sep 29;371(6496):389-95 PMID: 7522305
  10. Physiology of B cells in mice with X-linked immunodeficiency (xid). III. Disappearance of xid B cells in double bone marrow chimeras.
    J Exp Med. 1984 Sep 1;160(3):711-23 PMID: 6381637
  11. Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics.
    J Immunol. 1992 Oct 15;149(8):2533-40 PMID: 1383316
  12. Evidence for a ligand-mediated positive selection signal in differentiation to a mature B cell.
    J Immunol. 2003 Dec 15;171(12):6381-8 PMID: 14662836
  13. Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen.
    Proc Natl Acad Sci U S A. 1980 Mar;77(3):1602-6 PMID: 6966401
  14. Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers.
    Curr Biol. 2001 Dec 11;11(24):1986-9 PMID: 11747827
  15. Most peripheral B cells in mice are ligand selected.
    J Exp Med. 1991 Jun 1;173(6):1357-71 PMID: 1903427
  16. Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling.
    Nature. 2004 Sep 23;431(7007):456-61 PMID: 15361883
  17. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology.
    Biochem J. 2004 Sep 1;382(Pt 2):393-409 PMID: 15214841
  18. Defective B cell tolerance checkpoints in systemic lupus erythematosus.
    J Exp Med. 2005 Mar 7;201(5):703-11 PMID: 15738055
  19. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
    J Exp Med. 1999 Jun 7;189(11):1747-56 PMID: 10359578
  20. The role of cellular competition in B cell survival and selection of B cell repertoires.
    Eur J Immunol. 1995 Jun;25(6):1729-38 PMID: 7615000
  21. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.
    Cell. 1997 Sep 19;90(6):1073-83 PMID: 9323135
  22. Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer.
    Cell. 2004 Jun 11;117(6):787-800 PMID: 15186779
  23. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators.
    J Immunol. 2002 Jun 15;168(12):5993-6 PMID: 12055205
  24. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells.
    J Immunol. 1993 Nov 1;151(9):4431-44 PMID: 8409411
  25. Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation.
    Immunity. 2006 Jun;24(6):729-739 PMID: 16782029
  26. BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway.
    J Exp Med. 2005 Nov 21;202(10):1363-74 PMID: 16301744
  27. Resource competition as a mechanism for B cell homeostasis.
    Proc Natl Acad Sci U S A. 1997 May 27;94(11):5792-7 PMID: 9159153
  28. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.
    Science. 1999 Jul 9;285(5425):260-3 PMID: 10398604
  29. A B-cell receptor-specific selection step governs immature to mature B cell differentiation.
    Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2743-8 PMID: 10688906
  30. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.
    Science. 2001 Sep 14;293(5537):2111-4 PMID: 11509691
  31. TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.
    J Immunol. 2004 Aug 15;173(4):2245-52 PMID: 15294936
  32. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.
    Immunity. 2006 Sep;25(3):403-15 PMID: 16973390
  33. BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.
    Nat Immunol. 2002 Oct;3(10):958-65 PMID: 12352969
  34. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens.
    Nature. 1991 Oct 24;353(6346):765-9 PMID: 1944535
  35. IkappaB kinase signaling is essential for maintenance of mature B cells.
    J Exp Med. 2002 Sep 16;196(6):743-52 PMID: 12235208
  36. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.
    Immunity. 2004 Apr;20(4):441-53 PMID: 15084273
Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
DOI
10.1016/j.coi.2008.03.015
Published
2008-04-00
Epub
2008-00-02
Pages
158-61
Language
English
Region
England
NLM ID
8900118
PMCID
PMC2556951
Subset
IM
Grants
NIAID NIH HHS · R01 AI054488-04 · United States
NIAID NIH HHS · R01 AI054488 · United States
NIAID NIH HHS · R01 AI073939 · United States
NIAID NIH HHS · R01-AI0545488 · United States
NHLBI NIH HHS · T32-HL07971 · United States
NHLBI NIH HHS · T32 HL007971 · United States
NIAID NIH HHS · R01 AI073939-01 · United States
NIAID NIH HHS · T32 AI055428 · United States
PHS HHS · R01-073939 · United States
External Links
PubMed source DOI: 10.1016/j.coi.2008.03.015 PMC Full Text View journal details
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