Home LiteratureArticle Details

PMID: 9159153 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Resource competition as a mechanism for B cell homeostasis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 11 ·1997-05-27 ·Pages 5792-7

McLean AR, Rosado MM, Agenes F, Vasconcellos R, Freitas AA

Abstract

Cellular competition for survival signals offers a cogent and appealing mechanism for the maintenance of cellular homeostasis [Raff, M. C. (1992) Nature (London) 356, 397-400]. We present a theoretical and experimental investigation of the role of competition for resources in the regulation of peripheral B cell numbers. We use formal ecological competition theory, mathematical models of interspecific competition, and competitive repopulation experiments to show that B cells must compete to persist in the periphery and that antigen forms a part of the resources over which B cells compete.

MeSH Terms

Animals Antibody Formation B-Lymphocytes/immunology,physiology Bone Transplantation/immunology Female Homeostasis Immunoglobulin Heavy Chains/biosynthesis,genetics,isolation & purification Immunoglobulin Light Chains/biosynthesis,genetics,isolation & purification Immunoglobulin mu-Chains/biosynthesis,genetics,isolation & purification Mice Mice, Inbred C57BL Mice, Transgenic Models, Immunological Models, Theoretical Muramidase/immunology Time Factors Whole-Body Irradiation

Chemicals

Immunoglobulin Heavy Chains Immunoglobulin Light Chains Immunoglobulin mu-Chains Muramidase

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

McLean A R

Laboratoire des Dynamiques Lymphocytaires, Institut Pasteur, F-75724 Paris Cedex 15, France.

Rosado M M

Agenes F

Vasconcellos R

Freitas A A

References (27)

27 references, click to expand

Activation of B cell subsets by T-dependent and T-independent antigens.
Adv Exp Med Biol. 1978;98:339-56 PMID: 309712
Peptide competition for antigen presentation.
Immunol Today. 1990 Jan;11(1):21-4 PMID: 2405874
Social controls on cell survival and cell death.
Nature. 1992 Apr 2;356(6368):397-400 PMID: 1557121
The appearance of labeled cells in the thoracic duct lymph of the guinea pig after the administration of tritiated thymidine.
Blood. 1960 Jan;15:82-94 PMID: 13821053
Antigen-induced B-cell death and elimination during germinal-centre immune responses.
Nature. 1995 May 25;375(6529):334-8 PMID: 7753200
The turnover of B-cell populations.
Immunol Today. 1993 Jan;14(1):34-7 PMID: 8442861
Mathematical model of antiviral immune response. II. Parameters identification for acute viral hepatitis B.
J Theor Biol. 1991 Jul 7;151(1):41-69 PMID: 1943137
Anergic T cells as suppressor cells in vitro.
Science. 1994 Jun 10;264(5165):1587-9 PMID: 8202711
"Infectious" transplantation tolerance.
Science. 1993 Feb 12;259(5097):974-7 PMID: 8094901
The role of cellular competition in B cell survival and selection of B cell repertoires.
Eur J Immunol. 1995 Jun;25(6):1729-38 PMID: 7615000
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.
Nature. 1994 Sep 29;371(6496):389-95 PMID: 7522305
Experimental evidence that competition promotes divergence in adaptive radiation.
Science. 1994 Nov 4;266(5186):798-801 PMID: 17730400
The dynamic relationship between B-cell populations in adults.
Immunol Today. 1993 Jan;14(1):29-34 PMID: 8442859
Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate.
Immunity. 1995 Dec;3(6):691-701 PMID: 8777715
Lymphocyte lifespans: homeostasis, selection and competition.
Immunol Today. 1993 Jan;14(1):25-9 PMID: 8442858
Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.
Nature. 1995 May 25;375(6529):331-4 PMID: 7753199
The distribution of rapidly and slowly renewed T, B, and "null" lymphocytes in mouse bone marrow, thymus, lymph nodes, and spleen.
Cell Immunol. 1977 Sep;33(1):114-24 PMID: 302757
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.
Nature. 1988 Aug 25;334(6184):676-82 PMID: 3261841
Predation, apparent competition, and the structure of prey communities.
Theor Popul Biol. 1977 Oct;12(2):197-29 PMID: 929457
Evidence for a single-niche model of positive selection.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11694-8 PMID: 7972126
Global analysis of antibody repertoires. 1. An immunoblot method for the quantitative screening of a large number of reactivities.
Scand J Immunol. 1994 Jan;39(1):79-87 PMID: 8290896
Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice.
Cell. 1991 Aug 9;66(3):533-40 PMID: 1868548
Cellular competition modulates survival and selection of CD8+ T cells.
Eur J Immunol. 1996 Nov;26(11):2640-9 PMID: 8921950
Population kinetics of rat peripheral B cells.
J Exp Med. 1988 Mar 1;167(3):805-16 PMID: 3258353
Competition between foreign and self proteins in antigen presentation. Ovalbumin can inhibit activation of myelin basic protein-specific T cells.
J Immunol. 1990 Feb 15;144(4):1177-80 PMID: 1689345
Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line.
Nature. 1985 Mar 28-Apr 3;314(6009):330-4 PMID: 3920529
T cell repertoires and competitive exclusion.
J Theor Biol. 1994 Aug 21;169(4):375-90 PMID: 7967629

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.94.11.5792

Published

1997-05-27

Pages

5792-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC20859

Subset

External Links

PubMed source DOI: 10.1073/pnas.94.11.5792 PMC Full Text View journal details

Analysis Services

Resource competition as a mechanism for B cell homeostasis.

Contact

WeChat Official Account