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PMID: 18414734 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

A primer on ankyrin repeat function in TRP channels and beyond.

Molecular bioSystems ·Vol. 4 ·No. 5 ·2008-05-00 ·Pages 372-9

Gaudet R

Abstract

Transient receptor potential (TRP) channels are rapidly gaining attention as important receptors and transducers of diverse sensory and environmental cues. Recent progress in the field has provided new insights into the structure and function of the ankyrin repeat motifs present in the N-terminal cytosolic domain of many TRP channels. The topics addressed in this Highlight include the structural features of canonical ankyrin repeats, new clues into the functions these repeats perform in cells, and how this information can be applied to develop further experiments on TRP channels and other proteins containing ankyrin repeats.

MeSH Terms
Ankyrin Repeat/physiology Ligands Models, Molecular Protein Conformation Transient Receptor Potential Channels/chemistry,physiology
Chemicals
Ligands Transient Receptor Potential Channels
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gaudet Rachelle
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 01238, USA. gaudet@mcb.harvard.edu
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Article Info
Journal
Molecular bioSystems
Abbr.
Mol Biosyst
ISSN
1742-206X
DOI
10.1039/b801481g
Email
gaudet@mcb.harvard.edu
Published
2008-05-00
Epub
2008-00-26
Pages
372-9
Language
English
Region
England
NLM ID
101251620
PMCID
PMC3006086
Subset
IM
Grants
NIGMS NIH HHS · R01 GM081340 · United States
NIGMS NIH HHS · R01 GM081340-01A1 · United States
NIGMS NIH HHS · 1R01GM081340 · United States
External Links
PubMed source DOI: 10.1039/b801481g PMC Full Text View journal details
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