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PMID: 18381899 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Protein networks in disease.

Genome research ·Vol. 18 ·No. 4 ·2008-04-00 ·Pages 644-52

Ideker T, Sharan R

Abstract

During a decade of proof-of-principle analysis in model organisms, protein networks have been used to further the study of molecular evolution, to gain insight into the robustness of cells to perturbation, and for assignment of new protein functions. Following these analyses, and with the recent rise of protein interaction measurements in mammals, protein networks are increasingly serving as tools to unravel the molecular basis of disease. We review promising applications of protein networks to disease in four major areas: identifying new disease genes; the study of their network properties; identifying disease-related subnetworks; and network-based disease classification. Applications in infectious disease, personalized medicine, and pharmacology are also forthcoming as the available protein network information improves in quality and coverage.

MeSH Terms
Case-Control Studies Disease/classification Fungal Proteins/metabolism Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genetic Diseases, Inborn/genetics Genetic Predisposition to Disease Humans Huntington Disease/metabolism Phenotype Protein Interaction Mapping Yeasts/metabolism
Chemicals
Fungal Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ideker Trey
Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA.
Sharan Roded
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Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.071852.107
Published
2008-04-00
Pages
644-52
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC3863981
Subset
IM
Grants
NIEHS NIH HHS · R01 ES014811-01A1 · United States
NIGMS NIH HHS · R01 GM070743-03 · United States
NIEHS NIH HHS · R01 ES014811-05S1 · United States
NIGMS NIH HHS · R01 GM070743-04 · United States
NIEHS NIH HHS · R01 ES014811 · United States
NIGMS NIH HHS · R01 GM070743-03S1 · United States
NIEHS NIH HHS · ES14811 · United States
NIGMS NIH HHS · R01 GM070743-05 · United States
NIGMS NIH HHS · R01 GM070743-02 · United States
NIGMS NIH HHS · GM070743 · United States
NIGMS NIH HHS · R01 GM070743-01 · United States
NIGMS NIH HHS · R01 GM070743 · United States
NIEHS NIH HHS · R01 ES014811-04 · United States
NIEHS NIH HHS · R01 ES014811-05 · United States
NIEHS NIH HHS · R01 ES014811-02 · United States
NIEHS NIH HHS · R01 ES014811-03 · United States
NIEHS NIH HHS · R01 ES014811-02S1 · United States
External Links
PubMed source DOI: 10.1101/gr.071852.107 PMC Full Text View journal details
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