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PMID: 1837149 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 24 ·1991-12-15 ·Pages 11305-9

Pearse RN, Feinman R, Ravetch JV

Abstract

Expression of the high-affinity receptor for IgG (Fc gamma RI) is restricted to cells of myeloid lineage and is induced by gamma-interferon (IFN-gamma) but not by IFN-alpha/beta. The organization of the human Fc gamma RI gene has been determined and the DNA elements governing its cell type-restricted transcription and IFN-gamma induction are reported here. A 39-nucleotide sequence (IFN-gamma response region, or GRR) is defined that is both necessary and sufficient for IFN-gamma inducibility. Sequence analysis of the GRR reveals the presence of promoter elements initially defined for the major histocompatibility complex class II genes: i.e., X, H, and gamma-IRE sequences. Comparison of a number of genes whose expression is induced selectively by IFN-gamma indicates that the presence of these elements is a general feature of IFN-gamma-responsive genes. Our studies suggest that the combination of X, H, and gamma-IRE elements is a common motif in the pathway of transcriptional induction by this lymphokine.

MeSH Terms
Amino Acid Sequence Animals Antigens, Differentiation/drug effects,genetics,metabolism Base Sequence Cell Line Cosmids Female Genes/drug effects HeLa Cells Humans Immunoglobulin G/metabolism Interferon-gamma/pharmacology Mice Mice, Inbred A Molecular Sequence Data Placenta/immunology Plasmids Pregnancy Promoter Regions, Genetic/drug effects Receptors, Fc/drug effects,genetics,metabolism Receptors, IgG Restriction Mapping Sequence Homology, Nucleic Acid Transcription, Genetic/drug effects Transfection
Chemicals
Antigens, Differentiation Immunoglobulin G Receptors, Fc Receptors, IgG Interferon-gamma
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pearse R N
DeWitt Wallace Research Laboratory, Division of Molecular Biology, Sloan-Kettering Institute, New York, NY 10021.
Feinman R
Ravetch J V
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.24.11305
Published
1991-12-15
Pages
11305-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC53123
Subset
IM
Databases
GENBANK
M82818, M82819
External Links
PubMed source DOI: 10.1073/pnas.88.24.11305 PMC Full Text View journal details
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