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PMID: 18316475 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Migratory neighbors and distant invaders: tumor-associated niche cells.

Genes & development ·Vol. 22 ·No. 5 ·2008-03-01 ·Pages 559-74

Wels J, Kaplan RN, Rafii S, Lyden D

Abstract

The cancer environment is comprised of tumor cells as well as a wide network of stromal and vascular cells participating in the cellular and molecular events necessary for invasion and metastasis. Tumor secretory factors can activate the migration of host cells, both near to and far from the primary tumor site, as well as promote the exodus of cells to distant tissues. Thus, the migration of stromal cells and tumor cells among specialized microenvironments takes place throughout tumor and metastatic progression, providing evidence for the systemic nature of a malignancy. Investigations of the tumor-stromal and stromal-stromal cross-talk involved in cellular migration in cancer may lead to the design of novel therapeutic strategies.

MeSH Terms
Cell Movement Humans Neoplasm Invasiveness/pathology Neoplasm Metastasis/pathology Neoplasms/blood supply,drug therapy,pathology Neovascularization, Pathologic/pathology Stromal Cells/pathology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wels Jared
Department of Pediatrics, Weill Cornell Medical College, New York, NY 10021, USA.
Kaplan Rosandra N
Rafii Shahin
Lyden David
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.1636908
Published
2008-03-01
Pages
559-74
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC2731657
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NCI NIH HHS · R01 CA098234 · United States
NCI NIH HHS · R01 CA 098234 · United States
External Links
PubMed source DOI: 10.1101/gad.1636908 PMC Full Text View journal details
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