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PMID: 12465600 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

The macrophage growth factor CSF-1 in mammary gland development and tumor progression.

Journal of mammary gland biology and neoplasia ·Vol. 7 ·No. 2 ·2002-04-00 ·Pages 147-62

Lin EY, Gouon-Evans V, Nguyen AV, Pollard JW

Abstract

Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor prognosis. Studies of CSF-1 null mutant mice demonstrated that CSF-1 plays an important role in normal mammary ductal development as well as in mammary tumor progression to metastasis. CSF-1 regulates these processes through the recruitment and regulation of macrophages, cells that become associated with mammary tumors and the terminal end buds at the end of the growing ducts. This phenomenon suggests that the tumors subvert normal developmental processes to allow invasion into the surrounding stroma, a process that gives the tumor access to the vasculature and consequently the promotion of metastasis. In addition, soluble CSF-1 secreted from the tumor acts to divert antitumor macrophage responses and suppresses the differentiation of mature tumor-antigen-presenting dendritic cell This review discusses these observations in detail and attempts to fit them into a larger picture of CSF-1 and macrophage action in the regulation of normal mammary gland development and tumor progression.

MeSH Terms
Animals Breast/growth & development,metabolism,pathology Breast Neoplasms/etiology,genetics,metabolism,pathology Disease Progression Humans Macrophage Colony-Stimulating Factor/biosynthesis,genetics,physiology
Chemicals
Macrophage Colony-Stimulating Factor
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lin Elaine Y
Center for Study of Reproductive Biology and Women's Health, Departments of Developmental and Molecular Biology and Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, New York, New York 10461, USA.
Gouon-Evans Valerie
Nguyen Andrew V
Pollard Jeffrey W
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1020399802795
Published
2002-04-00
Pages
147-62
Language
English
Region
United States
NLM ID
9601804
Subset
IM
Grants
NIA NIH HHS · 5-T32-AG00194 · United States
NIAID NIH HHS · AI-CA09060 · United States
NCI NIH HHS · P30-CA13330 · United States
External Links
PubMed source DOI: 10.1023/a:1020399802795 View journal details
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