Macrophages in human breast disease: a quantitative immunohistochemical study.
We describe a quantitative histological study of 34 breast biopsies using a marker for human macrophages, the monoclonal antibody EBM/11. Seventeen of the biopsies were of malignant tumours. Both benign and malignant breast tissue contained large numbers of macrophages with significantly higher numbers occurring in the malignant group. An analysis was made of macrophage counts according to stage, grade and prognostic index of the malignant tumours. There was no correlation between macrophage numbers and any of these parameters in malignant breast tumours. We discuss the possible reasons why some earlier studies (using other markers such as lysozyme), have shown an apparently insignificant number of intratumoral macrophages.
20 references, click to expand
-
Possible host resistance in carcinoma of the breast: a histological study.Br J Cancer. 1968 Sep;22(3):383-401 PMID: 5681002
-
Immunohistochemical study on the distribution and significance of mononuclear cells in human breast carcinoma.Acta Pathol Jpn. 1986 Oct;36(10):1455-68 PMID: 3026138
-
Studies on the role of macrophages in regulation of growth and metastasis of murine chemically induced fibrosarcomas.Int J Cancer. 1975 Dec 15;16(6):1022-9 PMID: 1201871
-
Macrophage infiltration of breast tumours: a prospective study.J Clin Pathol. 1977 Jun;30(6):563-8 PMID: 874114
-
Immunofluorescent localization of alpha-1-antitrypsin in human polymorphonuclear leukocytes.Life Sci. 1978 Jan;22(1):99-104 PMID: 342855
-
Expression of monocytic--histiocytic cytochemical markers in epithelial neoplasia.Am J Clin Pathol. 1979 Nov;72(5):789-94 PMID: 228545
-
Alpha-1-antitrypsin in human macrophages.J Clin Pathol. 1981 Sep;34(9):982-90 PMID: 6792245
-
A prognostic index in primary breast cancer.Br J Cancer. 1982 Mar;45(3):361-6 PMID: 7073932
-
Lysozyme in human gastric carcinoma: a retrospective immunohistochemical study.Histopathology. 1982 Jul;6(4):409-21 PMID: 6749639
-
Production of a tumor cytolytic factor(s) by activated human alveolar macrophages and its action.Cancer Res. 1984 Feb;44(2):646-51 PMID: 6692369
-
Expression of major histocompatibility antigens and leucocyte infiltration in benign and malignant human breast disease.Br J Cancer. 1984 Feb;49(2):161-72 PMID: 6365133
-
Monoclonal antibodies specific for human monocytes, granulocytes and endothelium.Immunology. 1984 Dec;53(4):753-67 PMID: 6389324
-
Characterisation of macrophages infiltrating human mammary carcinomas.Br J Cancer. 1985 Jan;51(1):135-8 PMID: 3155620
-
Kinetics and function of tumor cytotoxic factor(s) produced by human blood monocytes activated to the tumoricidal state.J Natl Cancer Inst. 1985 Mar;74(3):583-90 PMID: 3856062
-
An immunohistological study of leukocyte localization in benign and malignant breast tissue.Int J Cancer. 1985 Oct 15;36(4):433-8 PMID: 3930410
-
Intraepithelial lymphocytes and macrophages in the normal breast.Virchows Arch A Pathol Anat Histopathol. 1985;407(4):369-78 PMID: 3931340
-
Phenotype and functions of intratumoral macrophages.Biochim Biophys Acta. 1986 Aug 5;865(1):27-41 PMID: 3524684
-
Osteoclasts contain macrophage and megakaryocyte antigens.J Pathol. 1986 Dec;150(4):239-46 PMID: 3806282
-
Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.Br J Cancer. 1957 Sep;11(3):359-77 PMID: 13499785
-
Macrophage content of tumours in relation to metastatic spread and host immune reaction.Nature. 1974 Aug 23;250(5468):667-9 PMID: 4546859
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