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PMID: 18157121 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation.

Nature cell biology ·Vol. 10 ·No. 2 ·2008-02-00 ·Pages 186-93

Aulehla A, Wiegraebe W, Baubet V, Wahl MB, Deng C, Taketo M, Lewandoski M, Pourquié O

Abstract

Rhythmic production of vertebral precursors, the somites, causes bilateral columns of embryonic segments to form. This process involves a molecular oscillator--the segmentation clock--whose signal is translated into a spatial, periodic pattern by a complex signalling gradient system within the presomitic mesoderm (PSM). In mouse embryos, Wnt signalling has been implicated in both the clock and gradient mechanisms, but how the Wnt pathway can perform these two functions simultaneously remains unclear. Here, we use a yellow fluorescent protein (YFP)-based, real-time imaging system in mouse embryos to demonstrate that clock oscillations are independent of beta-catenin protein levels. In contrast, we show that the Wnt-signalling gradient is established through a nuclear beta-catenin protein gradient in the posterior PSM. This gradient of nuclear beta-catenin defines the size of the oscillatory field and controls key aspects of PSM maturation and segment formation, emphasizing the central role of Wnt signalling in this process.

MeSH Terms
Animals Biological Clocks/physiology Body Patterning/physiology Cell Nucleus/metabolism Mesoderm/embryology,metabolism Mice Mice, Transgenic Mutation Signal Transduction/physiology Somites/embryology,metabolism Wnt Proteins/metabolism beta Catenin/genetics,metabolism
Chemicals
Wnt Proteins beta Catenin
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Aulehla Alexander
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Wiegraebe Winfried
Baubet Valerie
Wahl Matthias B
Deng Chuxia
Taketo Makoto
Lewandoski Mark
Pourquié Olivier
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Article Info
Journal
Nature cell biology
Abbr.
Nat Cell Biol
ISSN
1476-4679
Published
2008-02-00
Epub
2007-00-23
Pages
186-93
Language
English
Region
England
NLM ID
100890575
PMCID
PMC7391962
Subset
IM
Grants
Intramural NIH HHS · Z01 BC010338 · United States
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