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PMID: 17668009 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6.

EMBO reports ·Vol. 8 ·No. 8 ·2007-08-00 ·Pages 784-9

Wittler L, Shin EH, Grote P, Kispert A, Beckers A, Gossler A, Werber M, Herrmann BG

Abstract

The vertebral column and skeletal muscles of vertebrates are derived from the paraxial mesoderm, which is laid down initially as two stripes of mesenchymal cells alongside the neural tube and subsequently segmented. Previous work has shown that the wingless-type MMTV integration site family (WNT), fibroblast growth factor- and Delta-Notch signalling pathways control presomitic mesoderm (psm) formation and segmentation. Here, we show that the expression of mesogenin 1, a basic helix-loop-helix transcription factor, which is essential for psm maturation, is regulated by synergism between WNT signalling and the T-box 6 transcription factor, involving a feed-forward control mechanism. These findings emphasize the crucial role of WNT signalling in the control of psm formation, maturation and segmentation.

MeSH Terms
Animals Basic Helix-Loop-Helix Transcription Factors/analysis,genetics,metabolism Embryonic Development Gene Expression Regulation, Developmental Mesoderm/chemistry,metabolism Mice Mice, Transgenic Promoter Regions, Genetic Signal Transduction T-Box Domain Proteins Transcription Factors/analysis,metabolism Wnt Proteins/metabolism beta-Galactosidase/analysis,genetics
Chemicals
Basic Helix-Loop-Helix Transcription Factors Msgn1 protein, mouse T-Box Domain Proteins Tbx6 protein, mouse Transcription Factors Wnt Proteins beta-Galactosidase
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Wittler Lars
Department of Developmental Genetics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany.
Shin Eun-ha
Grote Phillip
Kispert Andreas
Beckers Anja
Gossler Achim
Werber Martin
Herrmann Bernhard G
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1038/sj.embor.7401030
Published
2007-08-00
Epub
2007-00-13
Pages
784-9
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1978083
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.embor.7401030 PMC Full Text View journal details
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